丁新华,崔艾琳,李倩倩,徐莉莉,穆晶晶,童明辉.经直肠剪切波弹性成像对前列腺癌诊断价值的Meta分析[J].中国介入影像与治疗学,2017,14(8):499-503
经直肠剪切波弹性成像对前列腺癌诊断价值的Meta分析
Transrectal shear wave elastograpy in diagnosis of prostate cancers:Meta-analysis
投稿时间:2017-03-04  修订日期:2017-05-23
DOI:10.13929/j.1672-8475.201703007
中文关键词:  剪切波  弹性成像技术  前列腺肿瘤  活组织检测  Meta分析
英文关键词:Shear wave  Elastography imaging technique  Prostatic neoplasms  Biopsy  Meta-analysis
基金项目:
作者单位E-mail
丁新华 兰州大学第二医院超声3科, 甘肃 兰州 730030  
崔艾琳 兰州大学第二医院超声3科, 甘肃 兰州 730030  
李倩倩 兰州大学第二医院超声3科, 甘肃 兰州 730030  
徐莉莉 兰州大学第二医院超声3科, 甘肃 兰州 730030  
穆晶晶 兰州大学第二医院超声3科, 甘肃 兰州 730030  
童明辉 兰州大学第二医院超声3科, 甘肃 兰州 730030 Tongmh1962@126.com 
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中文摘要:
      目的 采用Meta分析评价经直肠剪切波弹性成像在前列腺癌诊断中的应用价值。方法 检索2016年12月以前有关经直肠剪切波弹性成像诊断前列腺癌的中、英文文献,按照诊断性试验的纳入标准筛选文献,采用Meta-Disc 1.4及Stata 12.0软件对纳入的文献进行Meta分析。结果 共纳入8篇文献,其中经直肠剪切波弹性成像诊断前列腺癌的研究有5篇,汇总分析后,其诊断前列腺癌的合并敏感度(SEN)为0.80[95% CI(0.75,0.84)],合并特异度(SPE)为0.75[95% CI(0.71,0.79)],阳性似然比(PLR)为3.60[95% CI(2.57,5.05)],阴性似然比(NLR)为0.17[95% CI(0.08,0.37)],SROC曲线下面积(AUC)为0.895。经直肠剪切波弹性成像辅助下穿刺诊断前列腺癌的研究亦是5篇,汇总分析后,其合并SEN为0.86[95% CI(0.83,0.88)],SPE为0.84[95% CI(0.82,0.85)],PLR为5.81[95% CI(3.07,10.99)],NLR为0.14[95% CI(0.04,0.49)],SROC曲线下面积(AUC)为0.924。结论 经直肠剪切波弹性成像在前列腺癌诊断中有较好临床应用价值,且可作为经直肠超声引导下前列腺穿刺的辅助方法。
英文摘要:
      Objective To systematically analyze and assess the overall value of transrectal shear wave elastograpy in diagnosis of prostate cancer (PCa) using Meta-analysis. Methods Relevant Chinese and foreign papers diagnosing PCa with transrectal shear wave elastograpy published before December 2016 were searched. The references were evaluated and screened according to the criteria of diagnostic research. The selected references were analyzed by Meta-Disc 1.4 and Stata 12.0 statistical software. Results Eight articles were included in the present Meta-analysis. Five of these literatures were about transrectal shear wave elastograpy in diagnosis of PCa, the summarized sensitivity (SEN) and summarized specificity (SPE) in diagnosis of PCa were 0.80 (95%CI[0.75, 0.84]) and 0.75 (95%CI[0.71, 0.79]), respectively; the positive likelihood ratios (PLR) and negative likelihood ratios (NLR) were 3.60 (95%CI[2.57, 5.05]) and 0.17 (95%CI[0.08, 0.37]), respectively; the area under SROC curves was 0.895. Five of these literatures were about transrectal shear wave elastograpy supplemental prostatic biopsy in diagnosis of PCa, the summarized SEN and SPE were 0.86 (95%CI[0.83, 0.88]) and 0.84 (95%CI[0.82, 0.85]) respectively; the PLR and NLR were 5.81 (95%CI[3.07, 10.99]) and 0.14 (95%CI[0.04, 0.49]) respectively; the area under SROC curves were 0.924. Conclusion Transrectal shear wave elastograpy has better clinical value in detection of PCa and can be used to supplemental prostatic biopsy.
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