| 曾红春,王颖鑫,王俊华,韩伟,刘文亚.CEUS评价大鼠肝泡状棘球蚴病灶血流灌注的动态演变[J].中国介入影像与治疗学,2017,14(9):566-570 |
| CEUS评价大鼠肝泡状棘球蚴病灶血流灌注的动态演变 |
| CEUS in dynamicly assessing blood perfusion of hepatic alveolar echinococcosis in rats |
| 投稿时间：2017-03-17 修订日期：2017-07-09 |
| DOI：10.13929/j.1672-8475.201703026 |
| 中文关键词: 泡状棘球蚴 肝 超声检查 |
| 英文关键词:Alveolar echinococcosis Liver Ultrasonography |
| 基金项目:国家自然科学基金（81460267）。 |
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| 中文摘要: |
| 目的 探讨CEUS评价不同时期大鼠肝泡状棘球蚴病（HAE）血流灌注的价值。方法 采用CEUS观察70只成功感染HAE的大鼠在接种后不同时期（9、28、50周）的血流灌注特征，并与病理结果对照。结果 接种9周时55个（55/70，78.57%）病灶表现为高回声，15个（15/70，21.43%）病灶表现为混合性回声，病理表现为乳白色单/多囊泡样结构。随接种时间的延长（28、50周），病灶最大径逐渐增大，病灶内部实性成分及钙化灶逐渐增多，部分病灶可出现液化坏死。镜下病灶周边纤维组织逐渐增厚，周边见微血管聚集区。接种9周时CEUS显示病灶呈环状强化及分隔样强化，28周及50周时呈环状强化或伴细线样强化及无强化。CEUS后病灶边缘增强带最大宽度与病灶最大径比值随接种时间延长而逐渐减小（P=0.02）。结论 接种后不同时期大鼠HAE病灶的超声征象渐趋复杂，坏死区及钙化灶增加，CEUS可显示不同时期病灶周边及内部的血流灌注特征。 |
| 英文摘要: |
| Objective To evaluate the value of CEUS in dynamicly assessing the blood perfusion of hepatic alveolar echinococcosis (HAE) in rats.Methods The experimentally induced secondary HAE in totally 70 rats were studied at different time periods (9th week, 28th week, and 50th week) with CEUS, and compared to pathology results.Results At the 9th week, 55 HAE lesions (55/70, 78.57%) presented hyperechoic and the rest of 15 HAE lesions (15/70, 21.43%) presented mixed echogenicity. The single or multiple vesicular structures were found as pathological feature. At later stages (28th week and 50th week), the size of lesions increased compared to 9th week with more solid structures and the calcifications found in HAE lesions. Microscopically, the fibrous tissues surrounding the lesions gradually thickened and the microvascular accumulation were visible around the lesions. The HAE lesions at the 9th week showed the ring enhancement and central septa enhancement in CEUS. The HAE lesions at the 28th week and 50th week showed combinations of no enhancement, ring enhancement, and central septa enhancement in CEUS. The ratio of edge enhancement to maximum diameter of lesions decreased with the progression (P=0.02).Conclusion The ultrasonographic features in HAE lesions become more complicated with increasing calcifications and enlarged necrosis areas with the progression. The CEUS can reveal the dynamics of blood perfusion of HAE lesions at different stages. |
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