| 姜彬彬,张仲一,严昆,杨薇,吴薇,李荣杰,陈敏华.经皮超声引导下射频消融治疗胃癌肝转移疗效分析[J].中国介入影像与治疗学,2018,15(1):24-28 |
| 经皮超声引导下射频消融治疗胃癌肝转移疗效分析 |
| Outcome of percutaneous ultrasound-guided radiofrequency ablation for liver metastases from gastric cancer |
| 投稿时间：2017-07-12 修订日期：2017-10-16 |
| DOI：10.13929/j.1672-8475.201707019 |
| 中文关键词: 胃肿瘤 导管消融术 肿瘤转移 预后 |
| 英文关键词:Stomach neoplasms Catheter ablation Neoplasm metastasis Prognosis |
| 基金项目:首都临床特色应用研究与成果推广（Z151100004015186）。 |
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| 中文摘要: |
| 目的 探讨经皮超声引导下射频消融（RFA）治疗胃癌肝转移的疗效及预后因素。方法 回顾性分析55例接受经皮超声引导下RFA治疗的胃癌肝转移患者临床及影像学资料，观察评价患者总体生存率及预后影响因素。结果 55例（102个病灶）胃癌肝转移患者1、2、3、5年总体生存率分别为70.45%、42.90%、20.32%及10.16%。RFA治疗后1个月，肿瘤灭活率94.12%（96/102），肿瘤局部复发率15.69%（16/102），肝内新生转移灶发生率52.73%（29/55）。单因素分析示年龄（P=0.015）、肿瘤数目（P=0.011）、RFA前是否有肝外转移（P=0.026）、RFA后是否化疗（P=0.031）是影响患者生存的重要因素。多因素分析示年龄（P=0.033）、肿瘤数目（P=0.004）、RFA后是否化疗（P=0.001）是独立预后因素。RFA治疗后严重并发症的发生率为1.82%（1/55），未发生治疗相关性死亡。结论 经皮超声引导下RFA是一种安全、有效的胃癌肝转移治疗方式，年龄、肿瘤数量、RFA后联合化疗是影响患者预后的独立因素。 |
| 英文摘要: |
| Objective To investigate the efficacy and prognostic factors of percutaneous ultrasound-guided radiofrequency ablation (RFA) for liver metastases from gastric cancer. Methods Clinical and imaging data of 55 patients with liver metastasis from gastric cancer who underwent percutenous ultrasound-guided RFA were retrospectively analyzed, and the overall survival rates and prognostic factors were assessed. Results The overall survival rates of 1-, 2-, 3-and 5-year was 70.45%, 42.90%, 20.32% and 10.16%, respectively. The ablation rate was 94.12% (96/102) 1 month after RFA, and the local recurrent rate was 15.69% (16/102), the new metastasis rate was 52.73% (29/55). Age (P=0.015), tumor number (P=0.011), extrahepatic metastasis before RFA (P=0.026) and chemotherapy after RFA (P=0.031) were significantly prognostic factors. Age (P=0.033), tumor number (P=0.004) as well as chemotherapy after RFA (P=0.001) were independent prognostic factors. The severe complication rate was 1.82% (1/55), while no treatment-related death occurred. Conclusion Percutaneous ultrasound-guided RFA is a safe and effective therapeutic option for liver metastases from gastric cancer. Age, tumor number, chemotherapy after RFA are independent prognostic factors. |
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