| 张杰,鲁东,朱楠,吕维富,余永强.CT引导下经皮125I粒子植入治疗腹部转移性淋巴结[J].中国介入影像与治疗学,2018,15(3):129-133 |
| CT引导下经皮125I粒子植入治疗腹部转移性淋巴结 |
| CT-guided 125I seed implantation for treating abdominal metastatic lymph nodes |
| 投稿时间：2017-11-15 修订日期：2018-01-01 |
| DOI：10.13929/j.1672-8475.201711027 |
| 中文关键词: 淋巴结 肿瘤转移 近距离放射疗法 体层摄影术,X线计算机 |
| 英文关键词:Lymph nodes Neoplasm metastasis Brachytherapy Tomography,X-ray computed |
| 基金项目:国家卫计委医学科研专项项目（w2015xr13）、安徽省科技攻关项目（1704a0802152）。 |
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| 中文摘要: |
| 目的 探讨CT引导下125I粒子植入治疗腹部转移性淋巴结的安全性及疗效。方法 回顾性分析55例接受CT引导下放射性125I粒子植入治疗的患者资料，共63枚腹部转移性淋巴结，评价其治疗效果。结果 对55例患者均一次性成功植入125I粒子，术后验证辐射剂量达到术前计划要求。术后1、3、6、9、12个月客观有效率分别为76.19%（48/63）、80.65%（50/62）、71.43%（30/42）、77.50%（31/40）、78.95%（30/38），临床获益率分别为93.65%（59/63）、88.71%（55/62）、80.95%（34/42）、85.00%（34/40）、84.21%（32/38）。42例术前伴腹痛及腰背部疼痛患者术后1个月疼痛缓解39例（39/42，92.86%）。术中及术后均未发生骨髓抑制、大出血、感染等严重并发症。术后1、3、6、9、12个月患者生存率分别为100%、98.20%、61.80%、58.20%、54.50%。结论 CT引导下125I粒子植入是治疗腹部转移性淋巴结安全有效的方法之一。 |
| 英文摘要: |
| Objective To investigate the safety and efficacy of CT-guided 125I seed implantation in the treatment of metastatic lymph nodes within the abdomen. Methods Data of 55 patients who underwent CT-guided 125I seed implantation with a total of 63 metastatic lymph nodes within the abdomen were retrospectively analyzed. The efficacy was evaluated.Results 125I seeds were successfully implanted in all 55 patients, and the radiation dose reached the pre-operation plan requirements. The response rate of 1, 3, 6, 9 and 12 months after operation was 76.19%(48/63), 80.65%(50/62), 71.43%(30/42), 77.50%(31/40) and 78.95%(30/38), respectively. And the clinical benefit rate was 93.65%(59/63), 88.71%(55/62), 80.95%(34/42), 85.00%(34/40) and 84.21%(32/38), respectively. There were 42 patients combined with abdominal pain and back pain before the operation. Among them, 39 patients (39/42, 92.86%) relieved 1 month after operation. No severe complication occurred intraoperatively or postoperatively, such as inhibition of bone marrow, bleeding or infection. The survival rate of 1, 3, 6, 9 and 12 months postoperatively was 100%, 98.20%, 61.80%, 58.20% and 54.50%, respectively. Conclusion CT-guided 125I seed implantation is one of the safe and effective methods for treating metastatic lymph nodes within the abdomen. |
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