| 张碧辉,邹英华,范则扬,宋莉,杨敏,牛国晨.腔内去交感化对新西兰大白兔外周血管张力的影响[J].中国介入影像与治疗学,2018,15(3):171-174 |
| 腔内去交感化对新西兰大白兔外周血管张力的影响 |
| Effect of catheter-based peripheral sympathetic denervation on peripheral artery sympathetic tone of New Zealand rabbits |
| 投稿时间：2017-09-11 修订日期：2017-10-22 |
| DOI：10.13929/j.1672-8475.201708054 |
| 中文关键词: 外周去交感化治疗 外周血管交感神经张力 导管消融 周围动脉疾病 |
| 英文关键词:Catheter-based peripheral sympathetic denervation Peripheral artery sympathetic tone Catheter ablation Peripheral arterial disease |
| 基金项目:北京大学第一医院科研基金资助课题。 |
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| 中文摘要: |
| 目的 探讨腔内去交感化对新西兰大白兔外周血管张力的影响。方法 将20只新西兰大白兔随机分为实验组与对照组，每组各10只。对实验组兔行腹主动脉下段腔内射频消融后予去甲肾上腺素负荷，对照组直接给予同等剂量去甲肾上腺素负荷。以激光多普勒血流仪记录实验兔右后肢皮下血流灌注及温度。对比2组实验兔去甲肾上腺素负荷前（静息状态）与负荷后右后肢皮下血流灌注及皮温变化的差异。结果 分别对2组中各8只实验兔完成实验。实验组右后肢去甲肾上腺素负荷后较负荷前皮下血流变化幅度明显低于对照组[（-37.19±22.56）% vs（-57.02±10.12）%，P=0.04]。实验组去甲肾上腺素负荷后较负荷前右后肢皮温变化与对照组间差异无统计学意义[（0.35±0.50）℃ vs（-0.21±1.83）℃，P=0.43]。排除对照组温度变化明显异常的2只实验兔后，实验组与对照组去甲肾上腺素负荷前后皮温变化差异有统计学意义[（0.34±0.50）℃ vs（-1.14±0.72）℃，P<0.01]。结论 腔内去交感化治疗能够降低兔外周血管张力，改善其下肢缺血症状。 |
| 英文摘要: |
| Objective To investigate the effect of catheter-based peripheral sympathetic denervation (CPSD) on peripheral artery sympathetic tone of New Zealand rabbits. Methods Twenty New Zealand rabbits were randomly divided into CPSD group and control group(each n=10). Endovascular radiofrequency ablation above the bifurcation of the abdominal aorta was performed on the rabbits in CPSD group. Norepinephrine was infused with continuous trans-arterial pumping in both two groups. And laser Doppler flowmetry was used to measure the peripheral microperfusion and temperature of right hindlimb of rabbits. The changes of the peripheral microperfusion and temperature before (resting state) and after norepinephrine infused (norepinephrine load state) were compared between the two groups.Results Eight rabbits completed the procedure in each group. The change of peripheral microperfusion between resting and norepinephrine load states in CSPD group was lower than that in control group ([-37.19±22.56]% vs[-57.02%±10.12]%, P=0.04), whereas the change of temperature was not significantly different between the two groups ([0.35±0.50]℃ vs[-0.21±1.83]℃, P=0.43), while significant difference was noticed when two rabbits with abnormal temperature change in control group were neglected ([0.34±0.50]℃ vs[-1.14±0.72]℃, P<0.01). Conclusion CPSD can be used to decrease the peripheral artery sympathetic tone of New Zealand rabbits, and may play an important role in relieving symptoms of critical limb ischemia. |
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