| 郑智唯,赵云,刘朝奇.超声靶向破坏微泡在糖尿病基因治疗中的应用[J].中国介入影像与治疗学,2018,15(6):383-386 |
| 超声靶向破坏微泡在糖尿病基因治疗中的应用 |
| Application of ultrasound targeted microbubble destruction in gene therapy of diabetes mellitus |
| 投稿时间：2017-12-19 修订日期：2018-03-21 |
| DOI：10.13929/j.1672-8475.201712036 |
| 中文关键词: 糖尿病 微泡 基因疗法 |
| 英文关键词:Diabetes mellitus Microbubbles Gene therapy |
| 基金项目:国家自然科学基金（81473461）。 |
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| 摘要点击次数: 1076 |
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| 中文摘要: |
| 糖尿病是以高血糖为特征的代谢性疾病，常伴有各种组织，特别是眼、肾、心脏、血管、神经慢性损害和功能障碍，为治疗带来困难。近年来，糖尿病的基因治疗成为热点。超声靶向破坏微泡（UTMD）安全性高、重复性好，组织靶向高，已经成为基因潜在传递方法。本文就UTMD技术及其在糖尿病基因治疗中的研究进展进行综述。 |
| 英文摘要: |
| Diabetes mellitus is a metabolic disease characterized by hyperglycemia, resulting in chronic damage and dysfunction of many organs, such as the eyes, kidneys, heart, blood vessels, nerves, etc., which increase the difficulty of treatment for diabetes. In recent years, gene therapy for diabetes mellitus has become a hot topic. Ultrasound targeted microbubble destruction (UTMD) has the advantage of safety, good repeatability and tissue targeting, and has become a potential strategy for gene delivery. The related study progresses of UTMD in gene therapy of diabetes mellitus were reviewed in this article. |
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