| 孙伟航,张骜丹,隋吉栋,孙德光,王立明,李巍.中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值评价TACE后肝细胞癌患者预后[J].中国介入影像与治疗学,2018,15(12):722-726 |
| 中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值评价TACE后肝细胞癌患者预后 |
| Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in prediction of prognosis of patients with hepatocellular carcinoma after TACE |
| 投稿时间：2018-05-28 修订日期：2018-10-31 |
| DOI：10.13929/j.1672-8475.201805035 |
| 中文关键词: 肝肿瘤 淋巴细胞 中性粒细胞 血小板 化学栓塞,治疗性 |
| 英文关键词:Liver neoplasms Lymphocytes Neutrophil Blood platelets Chemoembolization,therapeutic |
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| 中文摘要: |
| 目的 探讨中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）预测TACE后肝细胞癌（HCC）患者预后的价值。方法 分析95例接受TACE治疗的BCLC分期B期的HCC患者资料，根据NLR、PLR值预测患者预后ROC曲线的界值，将其分成高值组和低值组。观察TACE术前、术后3天、术后1个月NLR和PLR变化及NLR、PLR值与术后生存期的相关性。结果 术后3天NLR高于术前（P<0.05），术后3天PLR低于术前（P<0.05）。术后1个月，NLR回落至接近术前水平（P>0.05），PLR上升至接近术前水平（P>0.05）。术前NLR≥2.51组中位总生存期（OS）短于NLR < 2.51组（13.40个月vs 26.83个月；Z=5.24，P<0.05）；术前PLR≥96.84组中位OS短于PLR < 96.84组（17.27个月vs 28.83个月；Z=3.06，P<0.05）。术后3天NRL≥5.17组中位OS短于NLR < 5.17组（15.20个月vs 25.07个月；Z=3.32，P<0.05）；术后3天PLR≥100.65组中位OS短于PLR < 100.65组（14.87个月vs 25.07个月；Z=3.54，P<0.05）。术前NLR水平、肿瘤最大径、AFP水平、AST水平、ALB水平是影响HCC患者TACE治疗预后的独立危险因素。结论 TACE治疗HCC前后NLR、PLR值与TACE后患者预后有关，可作为评估HCC患者预后的指标。 |
| 英文摘要: |
| Objective To investigate the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting prognosis of patients with hepatocellular carcinoma (HCC) after TACE. Methods Data of 95 patients with HCC (BCLC B) who were treated with TACE were analyzed retrospectively. The patients were divided into two groups according to the cut-off points of NLR and PLR ROC curve of prognosis, respectively. The changes of NLR and PLR before TACE, 3 days and 1 month after TACE, as well as the correlation of NLR and PLR with post TACE survival were observed. Results Three days after TACE, NLR increased (P<0.05), and PLR decreased (P<0.05). One month after TACE, NLR level dropped back to close to the preoperative level (P>0.05), and PLR rose back to close to preoperative level (P>0.05). The median overall survival (OS) in preoperative NLR ≥ 2.51 group was shorter than that of NLR<2.51 group (13.40 months vs 26.83 months; Z=5.24, P<0.05). The median OS in preoperative PLR ≥ 96.84 group was shorter than that of PLR<96.84 group (17.27 months vs 28.83 months; Z=3.06, P<0.05). The median OS in NLR ≥ 5.17 group 3 days after operation was shorter than that in NLR<5.17 group (15.20 months vs 25.07 months; Z=3.32, P<0.05), while in PLR ≥ 100.65 group 3 days after operation was shorter than that of PLR<100.65 group (14.87 months vs 25.07 months; Z=3.54, P<0.05). Preoperative NLR level, the maximum tumor diameter, alpha fetoprotein level, aspartate aminotransferase level and albumin level were independent risk factors for the prognosis of HCC patients treated with TACE. Conclusion NLR and PLR before and after TACE related to the prognosis of HCC patients treated with TACE, therefore could be used as indicators for patients prognosis. |
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