| 王旭杰,王梓函,程楷,李春梅,朱宗平,丁月云.载125I粒子链胃肠管长期留置治疗晚期食管癌的效果[J].中国介入影像与治疗学,2019,16(11):645-648 |
| 载125I粒子链胃肠管长期留置治疗晚期食管癌的效果 |
| Efficacy of long-term indwelling of gastrointestinal tube with 125I seed in treatment of advanced esophageal cancer |
| 投稿时间：2019-04-08 修订日期：2019-09-02 |
| DOI：10.13929/j.1672-8475.201904019 |
| 中文关键词: 食管肿瘤 碘同位素 介入治疗 |
| 英文关键词:esophageal neoplasms iodine isotopes interventional therapy |
| 基金项目:国家自然科学基金青年科学基金项目（81601524）。 |
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| 中文摘要: |
| 目的 探讨载125I粒子链胃肠管长期留置治疗晚期食管癌患者的效果。方法 对11例晚期食管癌患者给予载125I粒子链胃肠管长期留置，记录技术成功率，术前及术后2个月进食困难分级、食管病变最大层面的管壁厚度，统计治疗有效率及胸痛、出血等不良反应。结果 11例患者均成功置入载125I粒子链胃肠管，技术成功率为100%（11/11）。术后2个月时，11例患者进食困难均获不同程度改善，进食困难Stooler分级由术前的（3.55±0.52）级，降至（1.09±0.70）级；食管病变最大层面的管壁厚度由术前（21.65±4.50）mm，降至（11.38±4.20）mm，管壁厚度收缩率（48.89±10.50）%；治疗有效率为90.91%（10/11）；均未见食管瘘、出血等严重并发症。回收的鼻肠管均未出现断裂、粒子丢失及移位。结论 载125I粒子链胃肠管长期留置治疗晚期食管癌的效果较好。 |
| 英文摘要: |
| Objective To observe the efficacy of long-term indwelling of gastrointestinal tube with 125I seeds chains in patients with advanced esophageal cancer. Methods Long-term indwelling of gastrointestinal tube with 125I seeds chains were performed on 11 patients with advanced esophageal cancer. The success rate of operation was recorded. Eating difficulty classification (Stooler grade), wall thickness of esophageal lesions in the largest layer, effective rate and adverse reactions such as chest pain, bleeding were calculated before and 2 months after operation. Results The success rate of operation was 100% (11/11). Two months after operation, the 11 patients' eating difficulty improved at different degree, the Stooler grade of dysphagia decreased from preoperative (3.55±0.52)grade to (1.09±0.70)grade. The maximum wall thickness of esophageal lesions decreased from preoperative (21.65±4.50)mm to (11.38±4.20)mm after operation, and the wall thickness contraction rate was (48.89±10.50)%. The effective rate was 90.91% (10/11), without severe complications such as esophageal fistula and hemorrhage. No rupture, loss or displacement of 125I seeds was found on the recovered gastrointestinal tube. Conclusion Long-term indwelling of gastrointestinal tube with 125I seeds chains is effective in the treatment of advanced esophageal cancer. |
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