| 昝星有,李明,李娜,陆欣贤,刘明芃,朱巧英,周卫平.基于灰阶CEUS特征诊断三阴性乳腺癌[J].中国介入影像与治疗学,2019,16(11):687-690 |
| 基于灰阶CEUS特征诊断三阴性乳腺癌 |
| Diagnosis of triple negative breast cancer based on gray-scale contrast-enhanced ultrasonography |
| 投稿时间：2019-01-08 修订日期：2019-08-09 |
| DOI：10.13929/j.1672-8475.201901017 |
| 中文关键词: 乳腺肿瘤 三阴 超声检查 诊断显像 |
| 英文关键词:breast neoplasms triple negative ultrasonography diagnostic imaging |
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| 中文摘要: |
| 目的 探讨三阴性乳腺癌的灰阶CEUS特征及其诊断价值。方法 回顾性分析37例三阴性乳腺癌（TNBC）患者（TNBC组）及74例非三阴性乳腺癌（NTNBC）患者（NTNBC组），观察灰阶CEUS肿块内造影剂到达时间、达峰时间，测量造影剂达峰时病灶最大径。记录11项灰阶造影增强特征，包括内部强化特征、边缘强化特征、形态、边界、内部回声、周边放射状血管、内部充盈缺损及充盈缺损数量、强化方式、内部及周边扭曲或穿入血管、造影剂滞留。结果 TNBC组病灶最大径较NTNBC组明显增大[（25.26±10.33）mm vs（18.64±6.11）mm，t=4.445，P<0.001]，且2组间病灶边缘强化特征（χ2=6.518，P=0.011）、形态（χ2=15.686，P<0.001）、边界（χ2=12.727，P<0.001）、周边放射状血管（χ2=50.825，P<0.001）、内部充盈缺损（χ2=5.556，P=0.018）及充盈缺损数量（χ2=13.096，P<0.001）、强化方式（χ2=13.072，P<0.001）、造影剂滞留（χ2=17.731，P<0.001）差异均有统计学意义，其余灰阶CEUS特征指标在2组间差异均无统计学意义（P均>0.05）。结论 TNBC病灶较大且灰阶CEUS表现具有一定特征，有助于与NTNBC鉴别。 |
| 英文摘要: |
| Objective To investigate the gray-scale CEUS features and diagnostic value of triple negative breast cancer (TNBC). Methods Data of 37 TNBC patients (TNBC group) and 74 non-triple negative breast cancer (NTNBC) patients (NTNBC group) were retrospectively analyzed. The arrival time and peak time of contrast agent in the mass of gray scale CEUS were observed, and the maximum diameter of the lesion was measured. A total of 11 features of gray scale contrast enhancement were recorded, including internal enhancement features, marginal enhancement features, morphology, margin, internal echoes, peripheral radial vessels, internal filling defects and the number of filling defects, enhancement type, internal and peripheral contorted or penetrating vessels, as well as contrast agent retention. Results The maximum diameter of lesions in TNBC group was significantly larger than that in NTNBC group ([25.26±10.33]mm vs[18.64±6.11]mm, t=4.445, P<0.001]). Moreover, there were statistically significant difference of marginal enhancement characteristics (χ2=6.518, P=0.011), morphology (χ2=15.686, P<0.001), margin (χ2=12.727, P<0.001), peripheral radial vessels (χ2=50.825, P<0.001), internal filling defects (χ2=5.556, P=0.018) and the number of filling defects (χ2=13.096, P<0.001), enhancement type (χ2=13.072, P<0.001) and contrast agent retention (χ2=17.731, P<0.001) between the two groups. No statistically significant difference was found between the two groups in the other characteristics of gray-scale CEUS (all P>0.05). Conclusion TNBC lesions are larger than NTNBC in general. Certain characteristics displayed in gray-scale CEUS are helpful to differential diagnosis of TNBC and NTNBC. |
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