李蕊蕊,黄薇园,陈峰.功能MRI评价鼻咽癌放射治疗后早期脑损伤研究进展[J].中国介入影像与治疗学,2020,17(1):51-54
功能MRI评价鼻咽癌放射治疗后早期脑损伤研究进展
Research progress of functional MRI in early brain injury after radiotherapy for nasopharyngeal carcinoma
投稿时间:2019-07-23  修订日期:2019-10-30
DOI:10.13929/j.issn.1672-8475.2020.01.015
中文关键词:  鼻咽肿瘤  脑损伤  放射性损伤  磁共振成像
英文关键词:nasopharyngeal neoplasms  brain injuries  radiation injuries  magnetic resonance imaging
基金项目:海南省重点研发计划(ZDYF2018141、ZDYF2019137)。
作者单位E-mail
李蕊蕊 海南省人民医院放射科, 海南 海口 570311
南华大学研究生院, 湖南 衡阳 421000 
 
黄薇园 海南省人民医院放射科, 海南 海口 570311  
陈峰 海南省人民医院放射科, 海南 海口 570311 fenger0802@163.com 
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中文摘要:
      颞叶放射性脑损伤是放射治疗鼻咽癌后最易发生且影响预后的严重神经系统并发症。早发现、早治疗是控制放射性脑损伤病情进展的关键。但当常规影像学检查发现异常时,脑损伤常已发展至不可逆转的中晚期阶段。功能MRI通过多个参数定量反映活体组织微观结构改变,为临床早期诊断放射性脑损伤提供可靠的影像学依据。目前用于评估放射性脑损伤的功能MRI技术有磁共振波谱成像、灌注加权成像、弥散加权成像、扩散张量成像及扩散峰度成像等。本文对功能MRI评价放射治疗鼻咽癌后早期脑损伤研究进展进行综述。
英文摘要:
      Radiation brain injury in the temporal lobe is the most common and severe neurological complication after radiotherapy for nasopharyngeal carcinoma. Early detection and treatment are the key to control the progress of radiation brain injury. However, when abnormal changes were found in conventional MRI, brain injury had developed to irreversible middle and late stage frequently. Functional MRI, including magnetic resonance spectroscopy imaging, perfusion-weighted imaging, diffusion-weighted imaging, diffusion-tensor imaging, and diffusion-kurtosis imaging, can quantitatively reflect the microstructure changes of tissues through many parameters. Some of the parameters could be considered as image markers for diagnosis of radiation brain injury in the early stage. Research advances of functional MRI in early brain injury after radiotherapy for nasopharyngeal carcinoma were reviewed in this article.
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