危安,张艳银,皮雅妮,阳仔怡,唐振华.超声造影定量分析颈动脉斑块预测缺血性脑卒中复发[J].中国介入影像与治疗学,2021,18(2):100-104
超声造影定量分析颈动脉斑块预测缺血性脑卒中复发
Contrast-enhanced ultrasound quantitative analysis of carotid plaque for predicting recurrence of ischemic stroke
投稿时间:2020-06-11  修订日期:2020-11-09
DOI:10.13929/j.issn.1672-8475.2021.02.009
中文关键词:  脑梗死  颈动脉斑块  预测  超声检查  超声造影
英文关键词:brain infarction  carotid plaque  forecasting  ultrasonography  contrast-enhanced ultrasound
基金项目:湖南省科技创新计划项目(2017SK50506)、湖南省卫生计生委科研计划课题项目(B20180433)、长沙市指导性科技计划项目(ZD1702032)。
作者单位E-mail
危安 湖南省人民医院 湖南师范大学附属第一医院超声二科, 湖南 长沙 410005  
张艳银 湖南省人民医院 湖南师范大学附属第一医院超声二科, 湖南 长沙 410005  
皮雅妮 湖南省人民医院 湖南师范大学附属第一医院超声二科, 湖南 长沙 410005  
阳仔怡 湖南省人民医院 湖南师范大学附属第一医院超声二科, 湖南 长沙 410005  
唐振华 湖南省人民医院 湖南师范大学附属第一医院超声二科, 湖南 长沙 410005 37994907@qq.com 
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中文摘要:
      目的 探讨超声造影(CEUS)定量分析颈动脉斑块新生血管预测缺血性脑卒中(IS)复发的价值。方法 对150例首次临床诊断IS且伴颈动脉斑块患者行CEUS,根据随访12个月是否出现IS复发分为复发组(n=64)和未复发组(n=86);比较2组一般资料及CEUS时间-强度曲线(TIC)相关参数,包括始增时间、峰值时间、基线强度、强度峰值、增强强度值(EI)、上升时间、斜率及强度比值(Ratio)的差异,分析IS复发危险因素;采用ROC曲线法分析TIC相关参数预测IS复发的诊断效能。结果 复发组患者年龄、高血压、斑块强度峰值、EI值、斜率及Ratio值与未复发组差异均有统计学意义(P均<0.05)。EI值、Ratio值和高血压为IS复发的独立危险因素(P均<0.05)。EI值、Ratio值预测IS复发的AUC分别为0.81、0.80(Z=1.13,P=0.26)。结论 CEUS能有效检出颈动脉斑块内新生血管及其密度,对预测IS复发有一定参考价值。
英文摘要:
      Objective To investigate the value of contrast-enhanced ultrasound (CEUS) quantitative analysis of carotid plaque neovascularization in predicting recurrence of ischemic stroke (IS). Methods CEUS was performed on 150 patients with the first clinical diagnosed IS and carotid artery plaque. Then the patients were divided into recurrent group (n=64) and non-recurrent group (n=86) according to IS recurred or not during 12 months' follow-up. The general data and related parameters, including initial increase time, peak time, baseline intensity, peak intensity, enhancement intensity (EI), rise time, slope and intensity ratio (Ratio) of CEUS time-intensity curve (TIC) were compared between groups, and the risk factors of IS recurrence were analyzed. ROC curve method was used to analyze the diagnostic efficacy of TIC related parameters for predicting IS recurrence. Results Significant differences of age, hypertension, peak intensity, EI value, slope and Ratio were found between groups (all P<0.05). EI value, Ratio and hypertension were independent risk factors for IS recurrence (all P<0.05). AUC of EI value and Ratio for predicting IS recurrence was 0.81 and 0.80, respectively (Z=1.13,P=0.26). Conclusion CEUS could effectively detect the neovascularization and density of carotid artery plaques, having certain reference value for predicting IS recurrence.
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