| 付倩倩,吴翠萍,王诗雨,刘滢滢,康松,田家玮,姜双全.超声引导下微波消融治疗甲状腺良性结节效果及其影响因素[J].中国介入影像与治疗学,2021,18(7):393-397 |
| 超声引导下微波消融治疗甲状腺良性结节效果及其影响因素 |
| Efficacy and impact factors of ultrasound-guided microwave ablation for treatment of benign thyroid nodules |
| 投稿时间：2021-03-02 修订日期：2021-06-07 |
| DOI：10.13929/j.issn.1672-8475.2021.07.003 |
| 中文关键词: 甲状腺肿瘤 超声检查 微波消融 影响因素 |
| 英文关键词:thyroid neoplasms ultrasonography microwave ablation influencing factor |
| 基金项目: |
|
| 摘要点击次数: 1069 |
| 全文下载次数: 445 |
| 中文摘要: |
| 目的 观察超声引导下微波消融（MWA）治疗甲状腺良性结节的效果及其影响因素。方法 回顾性分析115例接受超声引导下MWA治疗的甲状腺单发良性结节患者，以术后12个月为随访终点，评价治疗效果，以结节体积缩小率（VRR）>90%为治愈，VRR ≤ 90%为未治愈。采用单因素及多因素Logistic回归分析筛选影响疗效的因素，并建立Logistic回归模型，以受试者工作特征（ROC）曲线分析回归模型预测疗效的效能。结果 术后1、3、6、12个月甲状腺结节体积逐渐减小（F=20.23，P<0.01），VRR逐渐增加（F=193.33，P<0.01）。单因素分析结果显示，治愈与未治愈结节之间，结节最大径、术前体积、回声、内部成分、血流分布、增强模式及术后即刻体积差异均有统计学意义（P均<0.05）。多因素Logistic回归分析结果显示，结节内部成分、增强模式及术后即刻体积是MWA疗效的独立影响因素（P均<0.05）。将结节内部成分（X1）、增强模式（X2）及消融术后即刻体积（X3）代入Logistic回归方程，建立回归模型，其预测MWA疗效的ROC曲线下面积为0.82，敏感度、特异度和准确率分别为67.50%、88.00%和79.13%。结论 超声引导下MWA治疗甲状腺良性结节安全、有效；结节内部成分、增强模式及消融术后即刻体积是疗效的独立影响因素。 |
| 英文摘要: |
| Objective To observe the efficacy of ultrasound-guided microwave ablation (MWA) for treatment of benign thyroid nodules, and to analyze the impact factors of therapeutic effect. Methods Data of 115 patients with solitary benign thyroid nodule who underwent ultrasound-guided MWA were retrospectively analyzed. Taken 12 months after operation as the end point of following-up, nodular volume reduction ratio (VRR)>90% as cured and VRR ≤ 90% as uncured, the therapeutic effects were evaluated. Univariate and multivariate Logistic regression analysis were used to screen the impact factors of efficacy, and Logistic regression model was established. Receiver operating characteristic (ROC) curve was drawn to observe the predicting efficacy of the model. Results At 1, 3, 6 and 12 months after operation, the volume of nodules continued to decrease (F=20.23, P<0.01) and VRR gradually increased (F=193.33, P<0.01). Univariate analysis results showed that there were statistically differences of the maximum diameter, preoperative volume, echo, internal compositions, blood flow distribution, enhancement mode and immediate volume after ablation between cured and uncured lesions (all P<0.05). Multivariate Logistic regression showed that the internal component of nodules, enhancement mode and immediate volume after ablation were independent impact factors for efficacy of ablation (all P<0.05). Taken internal component of the nodules (X1), enhancement mode (X2) and immediate volume after ablation (X3) into the Logistic regression equation, the results showed that the area under the ROC curve was 0.82, the sensitivity, specificity and accuracy was 67.50%, 88.00% and 79.13%, respectively. Conclusion Ultrasound-guided MWA was safe and effective in treatment of benign thyroid nodules. The internal composition of nodule, enhancement mode and immediate volume after ablation were independent impact factors for the efficacy of ablation. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
