李学达,杨莉莉,张浩,刘国平,张伟,李伟,刘士锋,王从晓,王松,胡效坤.对比观察不可逆电穿孔与射频消融治疗肝癌[J].中国介入影像与治疗学,2022,19(6):325-328
对比观察不可逆电穿孔与射频消融治疗肝癌
Comparative observation of irreversible electroporation and radiofrequency ablation in treatment of liver cancer
投稿时间:2021-12-23  修订日期:2022-04-06
DOI:10.13929/j.issn.1672-8475.2022.06.002
中文关键词:  肝肿瘤  不可逆电穿孔  射频消融  前瞻性研究
英文关键词:liver neoplasms  irreversible electroporation  radiofrequency ablation  prospective studies
基金项目:
作者单位E-mail
李学达 青岛大学附属医院介入医学中心, 山东 青岛 266000  
杨莉莉 青岛大学附属医院介入医学中心, 山东 青岛 266000  
张浩 青岛大学附属医院介入医学中心, 山东 青岛 266000  
刘国平 青岛大学附属医院介入医学中心, 山东 青岛 266000  
张伟 青岛大学附属医院介入医学中心, 山东 青岛 266000  
李伟 青岛大学附属医院介入医学中心, 山东 青岛 266000  
刘士锋 青岛大学附属医院介入医学中心, 山东 青岛 266000  
王从晓 青岛大学附属医院介入医学中心, 山东 青岛 266000  
王松 青岛大学附属医院介入医学中心, 山东 青岛 266000  
胡效坤 青岛大学附属医院介入医学中心, 山东 青岛 266000 huxiaokun770@163.com 
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中文摘要:
      目的 对比观察不可逆电穿孔(IRE)与射频消融治疗肝癌的安全性及疗效。方法 前瞻性纳入48例肝癌患者,随机将其分为试验组及对照组,每组24例。对试验组于全身麻醉下行CT引导下IRE消融;对照组于局部麻醉下行CT引导下射频消融;记录术中及术后不良反应,对比评价疗效。结果 对2组患者均顺利完成治疗,试验组1例死于对比剂过敏性休克,其余患者均未发生治疗相关3~4级严重不良反应及并发症。组间术后7天肿瘤消融成功率(96.43% vs. 96.97%)、术后30天(96.43% vs. 93.94%)及90天(89.29% vs. 90.91%)局部无复发率差异均无统计学意义(P均>0.05);术后各时间点总缓解率及疾病控制率差异亦无统计学意义(P均>0.05)。结论 IRE消融治疗肝癌效果明确、安全性高、不良反应轻,其局部控制肿瘤效果与射频消融治疗相当。
英文摘要:
      Objective To compare the safety and efficacy of irreversible electroporation (IRE) and radiofrequency ablation in treatment of liver cancer. Methods Forty-eight patients with liver cancer were prospectively collected and randomly divided into experimental group and control group (each n=24). CT-guided IRE ablation was performed under general anesthesia in experimental group, while CT-guided radiofrequency ablation under local anesthesia was performed in control group. The occurrence of intraoperative and postoperative adverse reactions, and the curative effect were evaluated and compared between groups. Results The operations were successfully completed in all patients. One case in experimental group died of contrast medium anaphylactic shock. There was no treatment-related grade 3—4 serious adverse reactions nor complications in both groups, no significant differences of the local recurrence free rate 7 days (96.43% vs. 96.97%), 30 days (96.43% vs. 93.94%) and 90 days (89.29% vs. 90.91%) after operations between groups (all P>0.05). No significant differences of the overall response rate nor disease control rate at each time point after operation between groups (all P>0.05). Conclusion IRE ablation had clear efficacy, high safety and light adverse reactions for treatment of liver cancer, with local tumor control effect similar to that of radiofrequency ablation.
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