张立甲,高毅,姜涵,邱新光.SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节[J].中国介入影像与治疗学,2022,19(6):352-355
SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节
SPECT combined with serum adiponectin for differential diagnosis of benign and malignant thyroid nodules
投稿时间:2021-12-14  修订日期:2022-03-21
DOI:10.13929/j.issn.1672-8475.2022.06.008
中文关键词:  甲状腺结节  脂联素  体层摄影术,发射型计算机,单光子  诊断,鉴别
英文关键词:thyroid nodule  adiponectin  tomography, emission-computed, single-photon  diagnosis, differential
基金项目:河南省高等学校重点科研项目(18A320008)。
作者单位E-mail
张立甲 新乡市中心医院 新乡医学院第四临床学院核医学科, 河南 新乡 453000 liyou741lian@163.com 
高毅 新乡市中心医院 新乡医学院第四临床学院核医学科, 河南 新乡 453000  
姜涵 新乡市中心医院 新乡医学院第四临床学院核医学科, 河南 新乡 453000  
邱新光 郑州大学第一附属医院甲状腺外科, 河南 郑州 450000  
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中文摘要:
      目的 分析SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节的效能。方法 回顾性分析815例单发甲状腺结节患者,术前均接受甲状腺SPECT显像及血清脂联素水平检测;以术后病理结果为金标准,采用受试者工作特征(ROC)曲线评估SPECT、血清脂联素及二者联合鉴别诊断甲状腺良、恶性结节的效能。结果 815枚甲状腺结节中,良性结节777枚(良性组),恶性结节38枚(恶性组),其血清脂联素水平分别为(12.65±1.45)ng/ml及(6.28±0.94)ng/ml,组间差异有统计学意义(P<0.001)。SPECT正确诊断恶性结节30枚、良性结节582枚,其鉴别诊断甲状腺良、恶性结节的曲线下面积(AUC)为0.783。以8.95 ng/ml为血清脂联素的截断点,正确诊断恶性甲状腺结节27例、良性544例,其AUC为0.723。SPECT联合血清脂联素正确诊断26例恶性、653例良性甲状腺结节, AUC为0.901。结论 SPECT联合血清脂联素鉴别诊断甲状腺良、恶性结节的效能较高。
英文摘要:
      Objective To explore the efficacy of SPECT combined with serum adiponectin for differential diagnosis of benign and malignant thyroid nodules. Methods Data of 815 patients with solitary thyroid nodules were retrospectively analyzed. All patients underwent thyroid SPECT imaging and serum adiponectin level detection before surgical resection. Taken postoperative pathological results as the gold standards, the receiver operating characteristic (ROC) curve was used to evaluate the efficacy of SPECT, serum adiponectin and both for differential diagnosis of benign and malignant thyroid nodules. Results Among 815 thyroid nodules, 777 were benign (benign group) and 38 were malignant ones (malignant group), with serum adiponectin levels of (12.65±1.45) ng/ml and (6.28±0.94) ng/ml, respectively, and the difference was statistically significant between groups (P<0.001). SPECT correctly diagnosed 30 malignant nodules and 582 benign nodules, and its area under the curve (AUC) for differentiating benign and malignant thyroid nodules was 0.783. Taken 8.95 ng/ml as the cut-off point of serum adiponectin, 27 cases of malignant thyroid nodules and 544 of benign thyroid nodules were correctly diagnosed, with AUC of 0.723. SPECT combined with serum adiponectin correctly diagnosed malignant thyroid nodules in 26 cases and benign thyroid nodules in 653 cases, and the AUC was 0.901. Conclusion SPECT combined with serum adiponectin had high efficacy for differential diagnosis of benign and malignant thyroid nodules.
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