| 宋珍珍,赵艳芬,刘祝,李兵.对比冷冻消融与微波消融治疗兔VX2椎旁肿瘤的有效性及安全性[J].中国介入影像与治疗学,2024,21(4):237-241 |
| 对比冷冻消融与微波消融治疗兔VX2椎旁肿瘤的有效性及安全性 |
| Comparison on efficacy and safety of cryoablation and microwave ablation for treating rabbit VX2 paravertebral tumors |
| 投稿时间：2023-12-21 修订日期：2024-01-25 |
| DOI：10.13929/j.issn.1672-8475.2024.04.011 |
| 中文关键词: 消融技术 兔 动物实验 椎旁肿瘤 |
| 英文关键词:ablation techniques rabbits animal experimentation paravertebral tumor |
| 基金项目:国家临床重点专科建设项目（川卫医政函［2023］87号） |
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| 中文摘要: |
| 目的 对比冷冻消融（CA）与微波消融（MWA）治疗兔VX2椎旁肿瘤的有效性及安全性。方法 选取48只新西兰大白兔建立VX2椎旁肿瘤模型并随机分为CA组（n=24）及MWA组（n=24），比较组间完全消融率、生存率、布里斯托尔兔疼痛量表（BRPS）评分及并发症发生率。结果 CA组完全消融率及治疗后21天生存率分别为91.67%（22/24）及33.33%（8/24），均高于MWA组［66.67%（16/24）及16.67%（4/24）］（P均＜0.05）。CA组治疗后4 h、1天、4天、7天及14天BRPS评分均低于MWA组（P均＜0.001）；2组上述时间点BRPS评分均低于治疗前（P均＜0.05）。CA组并发症发生率（3/24，12.50%）低于MWA组（8/24，33.33%）（P＜0.05）。结论 CA治疗兔VX2椎旁肿瘤的安全性及有效性均优于MWA。 |
| 英文摘要: |
| Objective To compare the efficacy and safety of cryoablation （CA） and microwave ablation （MWA） for treating rabbit VX2 paravertebral tumors. Methods Forty-eight New Zealand rabbits were selected to establish models of VX2 paravertebral tumor. The rabbits were then randomly divided into CA group （n=24） and MWA group （n=24）. The complete ablation rates, survival rates, Bristol rabbit pain scale （BRPS） scores and incidence of complications were compared between groups. Results The complete ablation rate and 21-day survival rate of CA group was 91.67% （22/24） and 33.33% （8/24）, both better than those of MWA group （66.67% ［16/24］ and 16.67% ［4/24］）, respectively （both P＜0.05）. BRPS scores of 4 h, 1 day, 4 days, 7 days and 14 days after treatment of CA group were all lower than those of MWA group （all P＜0.001）, and BRPS scores of both groups at the above time points were all lower than that before treatments （all P＜0.05）. The incidence of complications in CA group （3/24, 12.50%） was lower than in MWA group （8/24, 33.33%） （P＜0.05）. Conclusion The efficacy and safety of CA were both better than those of MWA for treating rabbit VX2 paravertebral tumors. |
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