徐振,何浩,许莺歌,闫磊,张松,朱明,吴垠垠,水少锋.抗凝与其联合介入方法治疗重症颅内静脉血栓形成[J].中国介入影像与治疗学,2024,21(5):276-280
抗凝与其联合介入方法治疗重症颅内静脉血栓形成
Anticoagulation alone and combining with intervention for treating severe cerebral venous thrombosis
投稿时间:2023-11-23  修订日期:2024-01-27
DOI:10.13929/j.issn.1672-8475.2024.05.005
中文关键词:  脑静脉  颅内血栓形成  溶栓疗法  血栓切除术
英文关键词:cerebral veins  intracranial thrombosis  thrombolytic therapy  thrombectomy
基金项目:
作者单位E-mail
徐振 郑州大学第一附属医院介入科, 河南 郑州 450052  
何浩 郑州大学第一附属医院介入科, 河南 郑州 450052  
许莺歌 郑州大学第一附属医院介入科, 河南 郑州 450052  
闫磊 郑州大学第一附属医院介入科, 河南 郑州 450052  
张松 郑州大学第一附属医院介入科, 河南 郑州 450052  
朱明 郑州大学第一附属医院介入科, 河南 郑州 450052  
吴垠垠 郑州大学第一附属医院介入科, 河南 郑州 450052  
水少锋 郑州大学第一附属医院介入科, 河南 郑州 450052 shuishaofeng@126.com 
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中文摘要:
      目的 对比单纯抗凝与其联合介入方法治疗重症颅内静脉血栓形成(CVT)的效果。方法 根据治疗方法将65例重症CVT患者纳入抗凝组(n=32)或联合组(n=33),比较组间入院、出院时改良Rankin量表(mRS)评分、患者预后、血管再通率,以及随访期间并发症发生率。结果 组间入院时mRS评分差异无统计学意义(P>0.05);联合组出院时mRS评分低于抗凝组(P<0.05)。出院时(84.85% vs. 59.38%)、出院后6个月(87.88% vs. 65.63%)及12个月(93.94% vs. 75.00%),联合组预后良好率均高于抗凝组(P均<0.05)。出院时联合组血管再通率高于抗凝组(100% vs. 75.00%,P<0.05)。截至随访末,组间并发症发生率差异无统计学意义(15.15%vs. 18.75%,P>0.05)。结论 对于重症CVT患者,相比单纯抗凝,以抗凝联合介入方法进行治疗可明显减轻症状、改善预后。
英文摘要:
      Objective To compare therapeutic efficacy of anticoagulation alone and combining with intervention for treating severe cerebral venous thrombosis (CVT). Methods Data of 65 severe CVT patients were retrospectively analyzed. The patients were divided into anticoagulation group (n=32) or combined group (n=33) according to therapeutic methods. The modified Rankin scale (mRS) score at admission and discharge, the prognosis of patients,vascular recanalization rate as well as incidence of complications during follow-up period were compared between groups. Results No significant difference of mRS scores at admission was found between groups (P>0.05), while mRS scores of combined group were lower than of anticoagulation group at discharge (P<0.05). The rate of good prognosis at discharge (84.85% vs. 59.38%), 6 months after discharge (87.88% vs. 65.63%) and 12 months after discharge (93.94% vs. 75.00%) in combined group were all higher than those in anticoagulation group (all P<0.05). The vascular recanalization rate in combined group was higher than that in anticoagulant group (100% vs. 75.00%, P<0.05). At the end of follow-up, no significant difference of complication incidence was found between groups (15.15% vs. 18.75%, P>0.05). Conclusion For patients with severe CVT, anticoagulation combined with interventional therapy could significantly alleviate clinical symptoms and improve prognosis compared with anticoagulation alone.
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