刘国平,葛美叶,李琳,任雅蔚,孔德茂,张妺,孟庆华,王子轩,王莉.经导管直接溶栓治疗下肢深静脉血栓形成的尿激酶量效分析[J].中国介入影像与治疗学,2013,10(1):11-14
经导管直接溶栓治疗下肢深静脉血栓形成的尿激酶量效分析
Analysis on dose and effect of urokinase in patients with lower limb deep vein thrombosis treated with catheter-directed thrombolysis
投稿时间:2012-10-22  修订日期:2012-12-22
DOI:
中文关键词:  导管插管溶栓术  静脉血栓形成  尿激酶
英文关键词:Catheter-directed  Venous thrombosis  Urokinase
基金项目:
作者单位E-mail
刘国平 青岛市市立医院介入放射科, 山东 青岛 266011 liu9812@126.com 
葛美叶 青岛市市立医院介入放射科, 山东 青岛 266011  
李琳 青岛市市立医院介入放射科, 山东 青岛 266011  
任雅蔚 青岛市市立医院介入放射科, 山东 青岛 266011  
孔德茂 青岛市市立医院介入放射科, 山东 青岛 266011  
张妺 青岛市市立医院介入放射科, 山东 青岛 266011  
孟庆华 青岛市市立医院介入放射科, 山东 青岛 266011  
王子轩 青岛市市立医院介入放射科, 山东 青岛 266011  
王莉 青岛市市立医院介入放射科, 山东 青岛 266011  
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中文摘要:
      目的 探讨经导管直接溶栓(CDT)治疗下肢深静脉血栓中尿激酶的合理用量。方法 将拟接受CDT的90例DVT患者随机分为3组:A组用小剂量尿激酶溶栓(每日用量<40万U),B组用中等剂量(每日用量40万~80万U),C组用大剂量(每日用量>80万U)进行溶栓治疗。比较3组的溶栓效果、溶栓时间及出血情况。结果 3组溶栓疗效差异有统计学意义(Hc=15.09,P<0.05),A组与B组疗效差异有统计学意义(t=1.99,P<0.05)。3组溶栓时间差异有统计学意义(F=4.92,P<0.05)。各组出血发生率差异无统计学意义(χ2=2.96,P>0.05),C组出血程度最重。结论 CDT治疗DVT安全有效,每日尿激酶用量在40万U~80万U时溶栓疗效好,且出血发生率低。
英文摘要:
      Objective To analyze the reasonable dosage of urokinase in patients with lower limb deep vein thrombosis (DVT) treated with catheter-directed thrombolysis (CDT). Methods Ninety patients with DVT who would be treated with CDT were randomly divided into three groups.Patients in group A were given with low dose of urokinase (<400 000 U per day, in group B with medium dose (400 000 U-800 000 U per day), while group C with larger dose urokinase (>800 000 U per day). The thrombolysis effect, thrombolytic treatment time and hemorrhage situation were compared among the three groups. Results The thrombolytic therapy effect were different among three groups (Hc=15.09, P<0.05). The effect were different between group A and group B (t=1.99, P<0.05). Thrombolytic time difference had statistical significance (F=4.92, P<0.05). No statistical significance of hemorrhage was found among three groups (χ2=2.96, P>0.05). Hemorrhage of group C was the most serious. Conclusion CDT for treatment of DVT is safe and effective. Using urokinase 400 000-800 000 U per day, the thrombolytic effect is good, and the rate of hemorrhage remains low.
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