| 杨倩,张明,王渊.多模态MRI观察颈椎源性疼痛患者全脑结构异常[J].中国医学影像技术,2020,36(9):1286~1291 |
| 多模态MRI观察颈椎源性疼痛患者全脑结构异常 |
| Multi-modality MRI observation on whole brain structure abnormalities in patients with cervical spondylotic pain |
| 投稿时间：2019-08-20 修订日期：2020-08-18 |
| DOI：10.13929/j.issn.1003-3289.2020.09.002 |
| 中文关键词: 疼痛 颈椎 脑 磁共振成像 灰质 白质 |
| 英文关键词:pain cervical vertebrae brain magnetic resonance imaging gray matter white matter |
| 基金项目:陕西省自然科学基础研究计划面上项目（2018JM7026）、西安市科技计划项目、西安交通大学基本科研业务费专项科研项目（xjj2018272）。 |
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| 中文摘要: |
| 目的 采用基于体素的形态学（VBM）技术和扩散张量成像（DTI）观察颈椎源性疼痛（CSP）患者全脑灰白质微结构异常，分析相应脑结构参数与临床特征的关系。方法 对31例CSP患者（CSP组）和30名年龄、性别匹配的健康志愿者（对照组）分别采集全脑3D-T1WI和DTI。对CSP组进行视觉模拟评分（VAS），对2组均行汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）及蒙特利尔认知能力（MoCA）评分。比较2组全脑灰质及白质微结构的差异，分析差异有统计学意义的参数与临床指标的相关性。结果 CSP组右侧楔前叶、右侧颞上回和右侧中扣带回灰质体积均较对照组减少，且与VAS评分均呈负相关（rs=-0.397、-0.402、-0.388，P均<0.05）。CSP组双侧上纵束各向异性分数（FA）值均减低，左侧上纵束FA值与VAS评分呈负相关（rs=-0.460，P=0.014）。CSP组结构异常脑灰白质参数与HAMA、HAMD和MoCA评分均无明显相关（P均>0.05）。结论 联合应用VBM技术及DTI可评估颈椎源性疼痛患者全脑灰白质微结构改变，包括右侧楔前叶、右侧颞上回、右侧中扣带回灰质体积减少伴双侧上纵束白质微结构异常。 |
| 英文摘要: |
| Objective To observe the microstructure abnormalities of gray matter and white matter in patients with cervical spondylotic pain (CSP) using voxel based morphometry (VBM) technology and diffusion tensor imaging (DTI). Methods Totally 31 CSP patients (CSP group) and 30 age and sex matched healthy volunteers (control group) underwent three dimensional T1 scanning of whole brain and DTI. Visual analogue scale (VAS) was performed on patients in CSP group, Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Montreal Cognitive Assessment (MoCA) were performed on both groups. The microstructures of brain gray matter and white matter were observed and compared between groups, and correlation of parameters being statistically different between groups with clinical indicators were analyzed. Results The gray matter volumes of the right precuneus, right superior temporal gyrus and right middle cingulum decreased in CSP group compare with those in control group, which were negatively correlated with VAS scores (rs=-0.397, -0.402, -0.388, all P<0.05). The fractional anisotropy (FA) values of bilateral superior longitudinal fasciculus in CSP group decreased, the FA value of the left superior longitudinal fasciculus was negatively correlated with VAS (rs=-0.460, P=0.014). No significant correlation of gray matter parameters of structural abnormalities and other clinical variables (HAMA, HAMD, and MoCA scores) was found in CSP group (all P>0.05). Conclusion VBM technique combined with DTI could be used to evaluate the microstructural changes gray matter and white matter of brain in CSP patients, including decreased gray matter volume of right precuneus, right superior temporal gyrus and right middle cingulum, accompanied by microstructural abnormalities of white matter in bilateral superior longitudinal fasciculus. |
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