| 管亚男,徐慧,金美琦.乳腺浸润性小叶癌MRI表现及其与Ki-67指数的相关性[J].中国医学影像技术,2020,36(9):1335~1339 |
| 乳腺浸润性小叶癌MRI表现及其与Ki-67指数的相关性 |
| MRI features of breast invasive lobular carcinoma and correlation with Ki-67 index |
| 投稿时间：2019-11-04 修订日期：2020-06-07 |
| DOI：10.13929/j.issn.1003-3289.2020.09.015 |
| 中文关键词: 乳腺肿瘤 磁共振成像 Ki-67抗原 |
| 英文关键词:breast neoplasms magnetic resonance imaging Ki-67 antigen |
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| 中文摘要: |
| 目的 观察乳腺浸润性小叶癌（ILC）MRI表现，分析其功能MRI参数与Ki-67指数的相关性。方法 回顾性分析184例经病理证实的乳腺癌患者，其中52例ILC（ILC组）、132例浸润性导管癌（IDC组），术前均接受乳腺MR检查。对比分析2组MRI形态学特征、血流动力学参数值及ADC值差异，探讨ILC组功能学参数值与Ki-67指数的相关性。结果 与IDC组比较，ILC组Ki-67指数降低（t=-3.50，P<0.01），更易出现非肿块样强化（χ2=48.74，P<0.01），ADC值及达峰时间（TTP）值均升高（t=2.48、2.98，P均<0.05）。ILC组Ki-67指数与ADC值呈负相关（r=-0.67，P<0.01），与早期强化率呈正相关（r=0.52，P<0.01）。结论 乳腺ILC的MRI表现有一定特征性，可为术前诊断ILC及评估预后提供参考。 |
| 英文摘要: |
| Objective To observe MRI features of breast invasive lobular carcinoma (ILC), and to analyze the relationship of functional MRI parameters and Ki-67 index. Methods Data of 184 patients with breast cancer confirmed pathologically were retrospectively analyzed, including 52 cases of ILC (ILC group) and 132 cases of invasive ductal carcinoma (IDC). All patients received preoperative breast MRI. MRI morphological manifestations and functional parameters were compared between 2 groups, and the relationships of functional MRI parameters and Ki-67 index of ILC were analyzed. Results Compared with those in IDC group, Ki-67 indexes in ILC group were lower (t=-3.50, P<0.01), while non-mass-like enhancement was more common (χ2=48.74, P<0.01), ADC and time to peak (TTP) value were both higher (t=2.48, 2.98, both P<0.05). Ki-67 index of ILC was negatively correlated with ADC value (r=-0.67, P<0.01) and positively correlated with early enhancement rate (r=0.52, P<0.01). Conclusion MRI findings of breast ILC had certain characteristics, providing references for preoperative diagnosis of ILC and prognosis assessment. |
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