黄文静,李鑫,王俊,樊凤仙,张鹏飞,张静.成人型神经元核内包涵体病MRI表现[J].中国医学影像技术,2021,37(9):1281~1285 |
成人型神经元核内包涵体病MRI表现 |
MRI manifestations of adult-onset neuronal intranuclear inclusion disease |
投稿时间:2020-07-17 修订日期:2021-06-21 |
DOI:10.13929/j.issn.1003-3289.2021.09.001 |
中文关键词: 神经元核内包涵体病 磁共振成像 |
英文关键词:neuronal intranuclear inclusion disease magnetic resonance imaging |
基金项目:国家自然科学基金(81960309)、兰州大学第二医院"萃英科技创新"计划(CY2018-MS02)。 |
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中文摘要: |
目的 观察成人型神经元核内包涵体病(NⅡD)MRI表现。方法 回顾性分析5例成人型NⅡD,观察病变位置、形态、信号特点及进展情况。结果 5例NⅡD均有不同程度大脑半球萎缩、侧脑室扩张及Fazekas 2级及以上脑白质病变,弥散加权成像(DWI)可见双侧大脑额叶皮髓质交界区对称性曲线样高信号,表观弥散系数(ADC)图呈低信号;液体衰减反转恢复(FLAIR)序列T2WI中,2例分别于小脑蚓部旁、小脑中脚见对称性片状高信号。治疗后, 1例DWI示双侧大脑额叶皮髓质交接区高信号扩展至双侧顶叶,1例FLAIR-T2WI示小脑蚓部旁高信号范围扩大。结论 DWI大脑额叶皮髓质交界区曲线样高信号为NⅡD的特征性MRI表现,有助于诊断。 |
英文摘要: |
Objective To observe MRI manifestations of adult-onset neuronal intranuclear inclusion disease (NⅡD). Methods Data of 5 patients with adult-onset NⅡD were retrospectively analyzed, and the location, morphology and signal characteristics of lesions and disease progression were observed.Results Different degrees of cerebral hemispheric atrophy were found in all 5 cases of NⅡD, accompanied by lateral ventricle dilation and white matter lesions of Fazekas grade 2 and above. Diffusion weighted imaging (DWI) showed symmetrically curvilinear hyperintense signals at the cortex-medulla junction of bilateral frontal lobes, which present as low signals in apparent diffusion coefficient (ADC) images. Fluid attenuated inversion recovery (FLAIR)-T2WI showed symmetrical patchy hyperintense signals in the cerebellar vermis and middle cerebellar peduncle in 2 cases, respectively. After treatment, DWI showed extension of hyperintense signals at the cortex-medulla junction of bilateral frontal lobes to bilateral parietal lobes in 1 case, while FLAIR-T2WI detected hyperintense signal near the cerebellar vermis enlarged in 1 case.Conclusion Curvilinear hyperintense signals at the cortex-medulla junction of bilateral frontal lobes on DWI was the characteristic MRI manifestation of NⅡD, which was helpful to diagnosis of NⅡD. |
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