| 白璐,郑安琪,李运轩,王卓楠,高俊刚,沈聪,高凡,段小艺.18F-PSMA-1007 PET/CT最大标准摄取值预测高危险度前列腺癌[J].中国医学影像技术,2021,37(9):1386~1390 |
| 18F-PSMA-1007 PET/CT最大标准摄取值预测高危险度前列腺癌 |
| 18F-PSMA-1007 PET/CT maximum standard uptake value for predicting high risk stratification prostate cancer |
| 投稿时间：2020-12-02 修订日期：2021-06-30 |
| DOI：10.13929/j.issn.1003-3289.2021.09.025 |
| 中文关键词: 前列腺肿瘤 正电子发射断层显像 危险度分层 |
| 英文关键词:prostatic neoplasms positron-emission tomography risk stratification |
| 基金项目:西安交通大学第一附属医院临床研究项目（XJTU1AF-CRF-2020-008）、西安交通大学第一附属医院新医疗新技术（XJYFY-2019J1）。 |
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| 中文摘要: |
| 目的 观察18F-PSMA-1007 PET/CT最大标准摄取值（SUVmax）预测高危险度前列腺癌（PCa）的价值。方法 回顾性分析经病理证实且接受18F-PSMA-1007 PET/CT检查的68例PCa患者，依据D'Amico危险分层标准将其分为低-中危组和高危组，比较组间各参数差异。以SUVmax构建高危PCa的Logistic回归模型，利用受试者工作特征（ROC）曲线评价其诊断效能。结果 68例PCa的SUVmax为25.652（16.670，38.355）；术前Gleason评分为8（7，9）分，术前平均总前列腺特异性抗原（tPSA）水平29.014（14.075，127.157）ng/ml。高危组（n=33）SUVmax为28.681（17.514，39.950）、tPSA为47.965（27.210，170.575）ng/ml，均高于低-中危组（n=35）的17.415（8.795，28.675）和13.345（6.958，18.443）ng/ml（P均<0.05）。以SUVmax建立的二分类Logistic回归模型预测高危PCa的ROC曲线下面积为0.773，截断值取0.78时，敏感度和特异度分别为81.62%和68.24%。结论 18F-PSMA-1007 PET/CT所示SUVmax可作为高危险度PCa的独立预测因子，为制定治疗方案及随访提供参考。 |
| 英文摘要: |
| Objective To explore the value of 18F-PSMA-1007 PET/CT maximum standard uptake value (SUVmax) for predicting high risk stratification prostate cancer (PCa). Methods Data of 68 patients PCa proved by biopsy pathology who underwent 18F-PSMA-1007 PET/CT scanning were retrospectively analyzed. According to D'Amico risk criteria, the patients were divided into low-medium risk group (n=35) and high risk group (n=33). Then relative parameters were compared between groups. A Logistic regression model for high risk PCa was established based on SUVmax, and the diagnostic efficiency of this model was evaluated with receiver operating characteristic (ROC) curve analysis. Results The median SUVmax was 25.652 (16.670, 38.355), the median preoperative Gleason score was 8(7, 9), and the median preoperative total prostate-specific antigen (tPSA) was 29.014 (14.075, 127.157) ng/ml of 68 cases of PCa. SUVmax was 28.681 (17.514, 39.950) and tPSA was 47.965 (27.210, 170.575) ng/ml in high risk group, higher than those in low-medium risk group (17.415 and 13.345 ng/ml, both P<0.05). The area under ROC curve of the Logistic regression model based on SUVmax was 0.773 (95%CI ). Taken 0.78 as the cut-off value, the sensitivity and specificity was 81.62% and 68.24%, respectively. Conclusion SUVmax of 18F-PSMA-1007 PET/CT could be used as an independent predictor of high-risk PCa, hence providing references for treatment planning and following-up. |
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