王燕,郑容.131I治疗分化型甲状腺癌骨转移疗效及其影响因素[J].中国医学影像技术,2021,37(9):1423~1426
131I治疗分化型甲状腺癌骨转移疗效及其影响因素
Efficacy and impact factors of 131I in treatment of differentiated thyroid cancer patients with bone metastases
投稿时间:2020-03-04  修订日期:2020-10-07
DOI:10.13929/j.issn.1003-3289.2021.09.036
中文关键词:  甲状腺肿瘤  肿瘤转移  碘放射性同位素  放射治疗
英文关键词:thyroid neoplasms  neoplasm metastasis  iodine radioisotopes  radiotherapy
基金项目:中国癌症基金会北京希望马拉松专项基金(LC2017A03)。
作者单位E-mail
王燕 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院核医学科, 北京 100021  
郑容 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院核医学科, 北京 100021 zrong99@163.com 
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中文摘要:
      131I治疗分化型甲状腺癌(DTC)骨转移疗效较好,可有效减轻骨痛、稳定或缩小骨转移灶,显著改善远期疗效,提高患者生存率。影响131I治疗DTC骨转移疗效的主要因素包括骨转移灶是否摄碘、131I累积剂量、年龄、病理类型、是否合并骨外器官转移、131I联合其他治疗手段、发现骨转移癌时间、是否存在临床骨相关事件及骨转移灶大小及数量。本文对131I治疗DTC骨转移效果及其影响因素进行综述。
英文摘要:
      131I has been proven effective in treatment of differentiated thyroid cancer (DTC) patients with bone metastases. 131I therapy can effectively relief bone pain, stabilize or shrink bone metastases, significantly improve the long-term efficacy and the survival rate of patients. The impact factors of the efficacy of 131I treatment of DTC bone metastases mainly included whether the lesions were radioiodine avid, cumulative 131I dose, age, pathological type, the presence of other distant metastases, combination with other treatments, the time of discovery of bone metastases, the presence of skeletal-related events, also the size and number of bone metastases. The efficacy and impact factors of 131I in treatment of patients with DTC bone metastasis were reviewed in this article.
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