| 张子怡,张滨滨,崔英健,韩赫,薛志孝.心脏CT血管造影用于左心耳封堵术：动物实验[J].中国介入影像与治疗学,2024,21(11):690-695 |
| 心脏CT血管造影用于左心耳封堵术：动物实验 |
| Cardiac CT angiography for left atrial appendage closure: Animal experiment |
| 投稿时间：2024-09-05 修订日期：2024-10-14 |
| DOI：10.13929/j.issn.1672-8475.2024.11.009 |
| 中文关键词: 犬 心房颤动 心耳 封堵器 体层摄影术，X线计算机 |
| 英文关键词:dogs atrial fibrillation atrial appendage occlude tomography,X-ray computed |
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| 中文摘要: |
| 目的 观察心脏CT血管造影（CCTA）用于左心耳封堵（LAAC）的价值。方法 对12只拉布拉多犬行LAAC，分别于LAAC前及其后7、45及90天行CCTA，记录治疗前左心耳（LAA）参数及治疗后封堵器压缩比；之后处死动物进行大体解剖观察、显微CT成像和病理学检查，分析CCTA用于LAAC的价值。结果 基于LAAC前CCTA测得LAA开口深度（18.8±2.6）mm、最小径（16.3±2.0）mm、最大径（22.6±3.2）mm，故选用28 mm直径封堵器。LAAC后7、45及90天CCTA均未见封堵器移位、血栓及装置泄露，各时间点所测压缩比差异无统计学意义（P＞0.05），且其后90天CCTA与显微CT所测压缩比差异亦无统计学意义（P＞0.05）。大体解剖显示11只犬封堵器完全内皮化、1只不完全内皮化；病理学见胶原纤维排列整齐，表面内皮细胞覆盖，未见炎性细胞浸润。结论 CCTA可于犬LAAC前评估LAA及其周围结构、指导选择封堵器、评估封堵效果及监测并发症。 |
| 英文摘要: |
| Objective To observe the value of cardiac CT angiography （CCTA） for left atrial appendage closure （LAAC）. Methods Twelve Labradors were enrolled and underwent LAAC. CCTA examinations were performed before and 7， 45 and 90 days after LAAC， and the left atrial appendage （LAA） parameters before and post LAAC occluder compression ratio were recorded. Ninety days after LAAC， the dogs were euthanized for gross anatomical observation， micro CT imaging and pathological examination， and the value of CCTA for LAAC was analyzed. Results Based on CCTA before LAAC， LAA opening depth was （18.8±2.6）mm， the minimum diameter was （16.3±2.0）mm and the maximum diameter was （22.6±3.2）mm， so 28 mm diameter occluders were selected for LAAC. Seven， 45 and 90 days after LAAC， no displacement of occluder， thrombi nor device leakage was found on CCTA， while no significant difference of compression ratio was found among different time points（P＞0.05）， nor between those measured with CCTA and micro CT 90 days after LAAC （P＞0.05）. Ninety days after LAAC， gross dissection revealed complete endothelialization of occlude in 11 dogs and incomplete endothelialization in 1 dog. Pathological examination showed that collagen fibers arranged neatly， with endothelial cells covering the surface， and no inflammatory cell infiltration was observed. Conclusion CCTA could be used to observe LAA and surrounding structures before LAAC， hence guiding to select appropriate occluder， evaluate occlusion effect and monitor complications of LAAC in dogs. |
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