| 顾海磊,唐文伟,田忠甫,张新露,姚尧,黄泽波.合成MRI及复合灵敏度编码弥散加权成像定量参数预测子宫内膜癌病理特征[J].中国介入影像与治疗学,2025,22(3):183-187 |
| 合成MRI及复合灵敏度编码弥散加权成像定量参数预测子宫内膜癌病理特征 |
| Quantitative parameters of synthetic MRI and multiplexed sensitivity encoding diffusion weighted imaging for predicting pathological characteristics of endometrial cancer |
| 投稿时间：2024-11-25 修订日期：2025-02-13 |
| DOI：10.13929/j.issn.1672-8475.2025.03.007 |
| 中文关键词: 子宫内膜肿瘤 磁共振成像 病理学 |
| 英文关键词:endometrial neoplasms magnetic resonance imaging pathology |
| 基金项目: |
|
| 摘要点击次数: 167 |
| 全文下载次数: 61 |
| 中文摘要: |
| 目的 观察合成MRI（syMRI）及复合灵敏度编码弥散加权成像（MUSE-DWI）定量参数预测子宫内膜癌（EC）病理特征的价值。方法 回顾性收集125例单发EC患者，基于术前syMRI及MUSE-DWI测量EC定量参数，包括T1、T2、质子密度（PD）及表观弥散系数（ADC）值。采用单因素分析及多因素logistic回归分析EC定量参数，获得EC不同病理特征的独立预测因素并建立联合模型；绘制受试者工作特征曲线，计算曲线下面积（AUC），评估模型预测效能。结果 125例EC中，Ⅰ型（雌激素依赖型）109例、Ⅱ型（非雌激素依赖型）16例；中低级别（31例G1级+63例G2级）94例、高级别（G3级）31例；低风险型（G1～2级Ⅰ型EC）93例、高风险型（G3级Ⅰ型+Ⅱ型EC）32例。其中84例EC肌层浸润＜1/2、41例≥1/2；41例存在脉管浸润；18例见淋巴结侵犯、105例无淋巴结侵犯，2例不详。Ⅰ型EC的T2值高于Ⅱ型（P＜0.05）；高级别或高风险型EC的T2及ADC值均低于中低级别或低风险型（P均＜0.05）；肌层浸润≥1/2 EC的T1、PD及ADC值均低于肌层浸润＜1/2 EC（P均＜0.05）；不同病理特征EC间其余MRI定量参数差异均无统计学意义（P均＞0.05）。ADC值为EC分级及风险类型，PD及ADC值均为EC肌层浸润的独立预测因素（P均＜0.05）。PD+ADC模型预测EC肌层浸润深度的AUC为0.739，与单一PD及ADC模型（0.692、0.707）差异均无统计学意义（P均＞0.05）。结论 syMRI及MUSE-DWI定量参数可用于临床预测EC病理特征。 |
| 英文摘要: |
| Objective To observe the value of quantitative parameters of synthetic MRI （syMRI） and multiplexed sensitivity encoding diffusion weighted imaging （MUSE-DWI） for predicting pathological characteristics of endometrial cancer （EC）. Methods Totally 125 patients with single EC were retrospectively collected. Quantitative parameters of EC， including T1， T2， proton density （PD） and apparent diffusion coefficient （ADC） values were measured based on preoperative syMRI and MUSE-DWI. Univariate analysis and multivariate logistic regression were performed to explore quantitative parameters of EC in order to screen independent predictors of EC with different pathologic characteristics for establishing combined models. Receiver operating characteristic curves were drawn， the area under the curves （AUC） were calculated to evaluate the predictive efficacy of models. Results Among 125 cases， type Ⅰ （estrogen-dependent type） and type Ⅱ （non-estrogen-dependent type） EC were found in 109 and 16 cases， respectively， including 94 cases of medium-low grade （31 of grade G1+63 of grade G2） and 31 cases of high grade （grade G3） EC， 93 low-risk type （grade G1—2 type Ⅰ EC） and 32 high-risk type （grade G3 type Ⅰ EC+type Ⅱ EC）， with muscular invasion＜1/2 in 84 cases and ≥1/2 in 41 cases. Meanwhile， vascular infiltration was found in 41 cases. Lymph node invasion was detected in 18 cases but not in 105 cases， which remained unclear in 2 cases. T2 value of type Ⅰ EC was higher than that of type Ⅱ EC （P＜0.05）. T2 and ADC values of high grade or high-risk type EC were lower than those of medium-low grade or low-risk type EC （all P＜0.05）. T1， PD and ADC values of EC with muscular invasion≥1/2 were all lower than of those with muscular invasion＜1/2 （all P＜0.05）. No significant difference of other quantitative MRI parameters was observed among EC with different pathological features （all P＞0.05）. ADC value was independent predictor of EC grade and risk type， PD and ADC values were both independent predictors of EC muscular invasion （all P＜0.05）. The AUC of PD+ADC model for predicting muscular invasion depth of EC was 0.739， which was not significantly different with that of single PD and ADC models （0.692 and 0.707） （both P＞0.05）. Conclusion Quantitative parameters of syMRI and MUSE-DWI could be used in clinical prediction of pathological characteristics of EC. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
