| 韦佳豪,刘学兵,孟庆国,李赵欢,吕霖漪.阿霉素致左心室心肌损伤兔早期左心房应变及左心房僵硬度指数改变[J].中国介入影像与治疗学,2025,22(5):341-345 |
| 阿霉素致左心室心肌损伤兔早期左心房应变及左心房僵硬度指数改变 |
| Early changes of left atrial strain and left atrial stiffness index in rabbits with left ventricular myocardial injury induced by adriamycin |
| 投稿时间：2025-04-27 修订日期：2025-05-17 |
| DOI：10.13929/j.issn.1672-8475.2025.05.009 |
| 中文关键词: 兔 阿霉素 心室功能，左 心房功能，左 超声心动描记术 |
| 英文关键词:rabbits doxorubicin ventricular function,left atrial function,left echocardiography |
| 基金项目:四川省财政厅 四川省科学技术厅省级科技计划项目（2024NSFSC0567）。 |
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| 中文摘要: |
| 目的 观察阿霉素（ADM）致左心室心肌损伤兔早期左心房应变及左心房僵硬度指数（LASI）改变。方法 将18只新西兰大白兔随机分为实验组（n=12）与对照组（n=6），每周分别注射ADM 2 mg/kg体质量或5 ml生理盐水，共4周。分别于注射ADM/生理盐水前、注射2及4周后行超声检查，获取左心房前后径（LAAPD）、左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）、二尖瓣侧壁瓣环舒张早期血流峰值流速（e）、二尖瓣口舒张早期血流峰值流速（E）/e、左心室整体纵向应变（LVGLS）、右心室整体长轴应变（RVCLS）、左心房储存期应变（LASr）、左心房管道期应变（LAScd）、左心房收缩期应变（LASct）及LASI并进行分析。结束超声检查后行病理学检查，观察心肌病理改变。结果 实验组注射4周后e显著低于该组注射前，以及对照组注射2及4周后（P均＜0.05）。不同时间点组间LASr、LAScd、LASct及LASI差异均有统计学意义（P均＜0.05）。实验组注射2及4周后上述参数与对照组差异均有统计学意义（P均＜0.05）；且各时间点LASr、LASct及LASI两两比较差异均有统计学意义（P均＜0.05），而注射前LAScd显著高于注射2及4周后（P均＜0.05）。病理学表现支持超声所见。结论 ADM致左心室心肌损伤兔早期即可出现左心房应变及LASI改变，且较LVGLS、RVCLS及LVEF等更为显著。 |
| 英文摘要: |
| Objective To observe early changes of left atrial strain and left atrial stiffness index （LASI） in rabbits with left ventricular myocardial injury induced by adriamycin （ADM）. Methods Eighteen New Zealand white rabbits were randomly divided into experimental group （n=12） and control group （n=6）， while 2 mg/kg ADM was injected into rabbits in experimental group and 5 ml physiological saline was injected into rabbits in control group every week for a total of 4 weeks. Ultrasound examination was performed before injection of ADM/physiological saline， 2 and 4 weeks after injection， respectively. Left atrial anteroposterior diameter （LAAPD）， left ventricular end diastolic diameter （LVEDD）， left ventricular ejection fraction （LVEF）， lateral wall of mitral ring of early peak flow velocity （e）， mitral valve orifice early peak flow velocity （E）/e， left ventricular global longitudinal strain （LVGLS）， right ventricular collectivity long axis strain （RVCLS）， left atrial strain during reservoir phase （LASr）， left atrial strain during conduit phase （LAScd）， left atrial strain during contraction phase （LASct） and LASI were obtained and analyzed. After ultrasound examination， myocardial changes were observed with pathological examination. Results Four weeks after injection， e in experimental group was significantly lower than that before injection， also lower than that 2 and 4 weeks after injection in control group （all P＜0.05）. Significant differences of LASr， LAScd， LASct and LASI were found among different time points between groups （all P＜0.05）. Two and 4 weeks after injection， the above 4 parameters in experimental group were all significantly different with those in control group （all P＜0.05）. LASr， LASct and LASI were different among different time points， while LAScd before injection was higher than that 2 and 4 weeks after injection in experimental group （all P＜0.05）. The pathological findings supported ultrasonic changes. Conclusion In early stage of ADM induced left ventricular myocardial injury in rabbits， changes of left atrial strain and LASI could be seen， which were more significant than those of LVGLS， RVCLS and LVEF， etc. |
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