| 王礼贤,袁悦,刘梦茵,王楠,梁雅坤,王翠菊.基于超声造影预测新辅助化疗用于上皮性卵巢癌效果[J].中国介入影像与治疗学,2025,22(12):775-779 |
| 基于超声造影预测新辅助化疗用于上皮性卵巢癌效果 |
| Contrast-enhanced ultrasound for predicting efficacy of neoadjuvant chemotherapy in epithelial ovarian cancer |
| 投稿时间：2025-11-04 修订日期：2025-11-24 |
| DOI：10.13929/j.issn.1672-8475.2025.12.005 |
| 中文关键词: 卵巢上皮性癌 超声检查 新辅助治疗 |
| 英文关键词:carcinoma,ovarian epithelial ultrasonography neoadjuvant therapy |
| 基金项目:河北省医学科学研究课题计划（20240611）。 |
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| 中文摘要: |
| 目的 观察超声造影（CEUS）预测新辅助化疗（NACT）用于上皮性卵巢癌（EOC）效果的价值。方法 回顾性选取于中间型肿瘤细胞减灭术前接受NACT的44例EOC患者，根据实体瘤疗效评价标准（RECIST）将其分为有效组（31例共45个病灶）与无效组（13例共14个病灶）；比较组间基线资料，以及NACT前、后超声参数及肿瘤标志物；绘制受试者工作特征曲线，计算曲线下面积（AUC），评估CEUS参数和肿瘤标志物预测NACT疗效的效能。结果 组间基线资料差异均无统计学意义（P均＞0.05）。有效组NACT前、后病灶最大径、收缩期峰值流速（PSV）、血流灌注指数（PI）、阻力指数（RI）、增强程度、增强时间、增强分布及时间-强度曲线（TIC）参数差异均有统计学意义（P均＜0.05）；无效组NACT前、后各超声参数差异均无统计学意义（P均＞0.05）。NACT后2组糖类抗原125（CA125）、人附睾蛋白4（HE4）及卵巢恶性肿瘤风险模型（ROMA）指数均明显低于NACT前（P均＜0.05）。CEUS TIC参数联合及肿瘤标志物联合预测EOC NACT效果的AUC分别为0.959及0.880，前者略高于后者，但差异无统计学意义（Z=1.577，P=0.115）。结论 CEUS有助于预测NACT用于EOC效果。 |
| 英文摘要: |
| Objective To observe the value of contrast-enhanced ultrasound （CEUS） for predicting the efficacy of neoadjuvant chemotherapy （NACT） in epithelial ovarian cancer （EOC）. Methods Totally 44 EOC patients who underwent NACT before interval cytoreductive surgery were retrospectively enrolled and divided into effective group （31 cases with 45 lesions） and ineffective group （13 cases with 14 lesions）. The baseline data were compared between groups， as well as ultrasonic parameters and tumor markers before and after NACT. The efficacy of CEUS parameters and tumor markers for predicting the efficacy of NACT were analyzed using the receiver operating characteristic curve and the area under the curve （AUC）. Results No significant difference of baseline data was found between groups （all P＞0.05）. In effective group， significant differences of the maximum diameter， peak systolic velocity （PSV）， perfusion index （PI）， resistance index （RI）， enhancement degree， enhancement time， enhancement distribution and time-intensity curve （TIC） parameters were found before and after NACT （all P＜0.05）， while no significant difference was found in ineffective group （all P＞0.05）. Carbohydrate antigen 125 （CA125）， human epididymitis protein 4 （HE4） and risk of ovarian malignancy algorithm （ROMA） index after NACT were significantly lower than those before NACT in both groups （all P＜0.05）. AUC of the combination of CEUS TIC parameters and tumor markers for predicting efficacy of NACT in EOC was 0.959 and 0.880， respectively， the former was slightly higher than the latter， but no significant difference was found （Z=1.577， P=0.115）. Conclusion CEUS was helpful for predicting the efficacy of NACT in EOC. |
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