| 刘婷,徐文健,鲁景元,陈皓月.比较以油溶性与水溶性对比剂行子宫输卵管造影后不孕症女性妊娠率：Meta分析[J].中国介入影像与治疗学,2025,22(12):785-790 |
| 比较以油溶性与水溶性对比剂行子宫输卵管造影后不孕症女性妊娠率：Meta分析 |
| Comparison on pregnancy rates in infertile women after hysterosalpingography with oil-soluble and water-soluble contrast medium: Meta-analysis |
| 投稿时间：2025-06-24 修订日期：2025-11-20 |
| DOI：10.13929/j.issn.1672-8475.2025.12.007 |
| 中文关键词: 不孕,女性 妊娠 子宫输卵管造影 对比剂 荟萃分析 |
| 英文关键词:infertility,female pregnancy hysterosalpingography contrast media meta-analysis |
| 基金项目:江苏省妇幼保健协会科研课题（FYX202010）。 |
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| 中文摘要: |
| 目的 采用荟萃分析比较以油溶性对比剂（OSCM）与水溶性对比剂（WSCM）行子宫输卵管造影（HSG）后不孕症女性妊娠率。方法 检索PubMed、Cochrane Library、Embase、Web of Science、中国知网、中国生物医学文献数据库、万方医学网及维普数据库自建库至2025年4月1日关于比较OSCM与WSCM HSG后不孕症女性妊娠率的文献；主要研究结局为临床妊娠及持续妊娠，次要结局为流产、异位妊娠、对比剂逆流及阴道出血。采用荟萃分析比较2组HSG后妊娠率。结果 最终纳入12篇文献共4 785例不孕症女性，OSCM组2 278例、WSCM组2 507例。OSCM组HSG后6个月内临床妊娠率及持续妊娠率均显著高于WSCM组（P均＜0.05），而HSG后7～12个月内及＞12个月差异无统计学意义（P均＞0.05）。HSG后OSCM组对比剂逆流发生率显著高于、而阴道出血率显著低于WSCM组（P均＜0.05）。结论 相比WSCM，以OSCM行HSG更有助于提高不孕症女性其后6个月内妊娠率、降低阴道出血风险。 |
| 英文摘要: |
| Objective To compare pregnancy rates in infertile women after hysterosalpingography （HSG） with oil-soluble contrast media （OSCM） and water-soluble contrast media （WSCM） using meta-analysis. Methods Literature of comparison on pregnancy rates in infertile women after HSG with OSCM and WSCM published in PubMed， Cochrane Library， Embase， Web of Science， CNKI， China Biology Medicine disc， Wanfang Med Online and VIP Databases were searched from establishment of database to April 1， 2025. The primary research outcomes were clinical pregnancy and ongoing pregnancy， the secondary outcomes included miscarriage， ectopic pregnancy， contrast agent reflux and vaginal bleeding. The pregnancy rates were compared between groups after HSG with meta-analysis. Results A total of 12 articles were ultimately selected， including 4 785 infertile women， 2 278 in OSCM group and 2 507 in WSCM group. The clinical pregnancy rate and ongoing pregnancy rate within 6 months after HSG in OSCM group were significantly higher than those in WSCM group （both P＜0.05）， while no significant difference was found within 7—12 months after HSG nor 12 months later （all P＞0.05）. After HSG， the incidence of contrast agent reflux in OSCM group was significantly higher， but the rate of vaginal bleeding was significantly lower than those in WSCM group （both P＜0.05）. Conclusion Compared HSG with WSCM， HSG with OSCM was more helpful for improving pregnancy rates in infertile women within 6 months and reducing the risk of vaginal bleeding. |
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