| 王赵榕,杭嘉乐,万芙蓉,彭莹莹,叶靖,罗先富.基于MR酰胺质子转移加权成像诊断粗梁-团块型肝细胞癌[J].中国介入影像与治疗学,2026,23(4):203-207 |
| 基于MR酰胺质子转移加权成像诊断粗梁-团块型肝细胞癌 |
| MR amide proton transfer-weighted imaging for diagnosis of macrotrabecular-massive hepatocellular carcinoma |
| 投稿时间：2025-12-17 修订日期：2026-01-24 |
| DOI：10.13929/j.issn.1672-8475.2026.04.003 |
| 中文关键词: 癌,肝细胞 磁共振成像 |
| 英文关键词:carcinoma,hepatocellular magnetic resonance imaging |
| 基金项目:扬州市科技计划（YZ2025380）。 |
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| 摘要点击次数: 13 |
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| 中文摘要: |
| 目的 观察MR酰胺质子转移加权（APTw）成像诊断粗梁-团块型肝细胞癌（MTM-HCC）的价值。方法 前瞻性纳入56例拟接受上腹部MR检查的肝占位患者，根据病理结果分为MTM-HCC组（n=12）与非MTM-HCC组（n=44）。行上腹部MR扫描，包括常规及APTw成像；比较组间MRI表现及相关参数，评估其诊断MTM-HCC效能。结果 组间肿瘤最大径、动脉期乏血供成分占比、坏死占比、根据改良Mulé标准诊断的MTM-HCC占比及APTw值差异均有统计学意义（P均＜0.05）；上述参数诊断MTM-HCC的曲线下面积（AUC）分别为0.667、0.678、0.667、0.652及0.775，以APTw值的AUC最高（P均＜0.05）。基于肿瘤最大径、改良Mulé标准及APTw值构建的联合模型的AUC为0.866，显著高于除APTw值外的任一单一项（P均＜0.05）。结论 MR APTw成像有助于诊断MTM-HCC。 |
| 英文摘要: |
| Objective To observe the value of MR amide proton transfer-weighted （APTw） imaging for diagnosis of macrotrabecular-massive hepatocellular carcinoma （MTM-HCC）. Methods Totally 56 patients with liver space-occupying lesion who would undergo upper abdominal MR examinations were prospectively enrolled and divided into MTM-HCC group （n=12） and non MTM-HCC group （n=44） based on pathology. Upper abdominal MR scanning was performed， including routine and APTw imaging. MR manifestations and parameters of tumors were compared between group， and their efficacy for diagnosing MTM-HCC was observed. Results Significant differences of tumor maximum diameter， the proportion of arterial phase avascular components， necrosis and MTM-HCC diagnosed according to the modified Mulé criteria， as well as of APTw value were found between groups （all P＜0.05）. The area under the curve （AUC） of the above ones for diagnosing MTM-HCC was 0.667， 0.678， 0.667， 0.652 and 0.775， respectively， and APTw value had highest AUC （all P＜0.05）.A combined model was constructed based on tumor maximum diameter， modified Mulé criteria and APTw value， and its AUC was 0.866， significantly higher than any single expression/parameter except APTw value （all P＜0.05）. Conclusion MR APTw imaging was helpful for diagnosing MTM-HCC. |
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