余格梅,胡蝶,刘莹,周鸿,蔡韦雯,文宏,李果,吴爽,周洋.肝脏及胰腺超声衍生脂肪分数联合临床参数诊断肥胖/超重人群胰岛素抵抗[J].中国介入影像与治疗学,2026,23(4):208-213
肝脏及胰腺超声衍生脂肪分数联合临床参数诊断肥胖/超重人群胰岛素抵抗
Ultrasound-derived fat fraction of liver and pancreas combined with clinical indicators for diagnosing insulin resistance in obese/overweight populations
投稿时间:2025-12-27  修订日期:2026-02-02
DOI:10.13929/j.issn.1672-8475.2026.04.004
中文关键词:  肥胖症  胰岛素抗药性  脂肪组织  超声检查
英文关键词:obesity  insulin resistance  adipose tissue  ultrasonography
基金项目:
作者单位E-mail
余格梅 川北医学院附属医院超声科, 四川南充 637000
西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 
 
胡蝶 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
刘莹 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
周鸿 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
蔡韦雯 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
文宏 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
李果 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
吴爽 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031  
周洋 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 zhouyang@swjtu.edu.cn 
摘要点击次数: 13
全文下载次数: 0
中文摘要:
      目的 观察肝脏及胰腺超声衍生脂肪分数(UDFF)联合临床参数诊断肥胖/超重人群胰岛素抵抗(IR)的价值。方法 回顾性纳入99例肥胖/超重者,根据有无IR分为IR组(n=45)与非IR组(n=54);另以45名健康体检者为对照组。比较3组间及两两组间临床及超声参数,以logistic回归分析筛选IR的影响因素;构建模型并评估其诊断效能。结果 3组间体质量指数(BMI)、腰围、腰臀比(WHR),甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、谷丙转氨酶、谷草转氨酶、空腹血糖、C肽(C-PR)、空腹胰岛素(FINS),以及肝脏UDFF及Emean、胰腺UDFF及胰头、胰体、胰尾Emean差异均有统计学意义(P均<0.05)。IR组与对照组上述参数差异均有统计学意义(P均<0.05);IR组与非IR组腰围、WHR、TG、HDL、C-PR、FINS及肝脏UDFF差异有统计学意义(P均<0.05)。WHR、TG、FINS及肝脏UDFF均为肥胖/超重人群IR的独立影响因素(P均<0.05),四者联合的曲线下面积为0.935。结论 联合WHR、TG、FINS及肝脏UDFF诊断肥胖/超重人群IR效能较好,而胰腺UDFF对IR无显著影响。
英文摘要:
      Objective To observe the value of ultrasound-derived fat fraction (UDFF) of liver and pancreas combined with clinical indicators for diagnosing insulin resistance (IR) in obese/overweight populations. Methods Totally 99 obese/overweight individuals were retrospectively included and divided into IR group (n=45) and non-IR group (n=54) based on the presence of IR,while 45 healthy physical examination participants were taken as controls (control group). Clinical and ultrasound parameters were compared among 3 groups and between each 2 groups. Logistic regression analysis was used to screen the impact factors of IR, then a model was constructed and its diagnostic efficacy was evaluated. Results Significant differences of body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, fasting blood glucose, C-peptide (C-PR), fasting insulin (FINS), liver UDFF and Emean, as well as of pancreatic UDFF and Emean of the head, body and tail of the pancreas were detected among 3 groups, also between IR group and control group (all P<0.05). Meanwhile, significant differences of waist circumference, WHR, TG, HDL, C-PR, FINS and liver UDFF were found between IR group and non-IR group (all P<0.05). WHR, TG, FINS and liver UDFF were all independent impact factors of IR in obese/overweight populations (all P<0.05), and the area under the curve of their combination was 0.935. Conclusion The combination of WHR, TG, FINS and liver UDFF had better efficacy for diagnosing IR in obese/overweight populations, while pancreatic UDFF had no significant impact on IR.
查看全文  查看/发表评论  下载PDF阅读器
关闭