| 余格梅,胡蝶,刘莹,周鸿,蔡韦雯,文宏,李果,吴爽,周洋.肝脏及胰腺超声衍生脂肪分数联合临床参数诊断肥胖/超重人群胰岛素抵抗[J].中国介入影像与治疗学,2026,23(4):208-213 |
| 肝脏及胰腺超声衍生脂肪分数联合临床参数诊断肥胖/超重人群胰岛素抵抗 |
| Ultrasound-derived fat fraction of liver and pancreas combined with clinical indicators for diagnosing insulin resistance in obese/overweight populations |
| 投稿时间:2025-12-27 修订日期:2026-02-02 |
| DOI:10.13929/j.issn.1672-8475.2026.04.004 |
| 中文关键词: 肥胖症 胰岛素抗药性 脂肪组织 超声检查 |
| 英文关键词:obesity insulin resistance adipose tissue ultrasonography |
| 基金项目: |
| 作者 | 单位 | E-mail | | 余格梅 | 川北医学院附属医院超声科, 四川南充 637000 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 胡蝶 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 刘莹 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 周鸿 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 蔡韦雯 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 文宏 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 李果 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 吴爽 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | | | 周洋 | 西南交通大学附属医院成都市第三人民医院超声科, 四川 成都 610031 | zhouyang@swjtu.edu.cn |
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| 中文摘要: |
| 目的 观察肝脏及胰腺超声衍生脂肪分数(UDFF)联合临床参数诊断肥胖/超重人群胰岛素抵抗(IR)的价值。方法 回顾性纳入99例肥胖/超重者,根据有无IR分为IR组(n=45)与非IR组(n=54);另以45名健康体检者为对照组。比较3组间及两两组间临床及超声参数,以logistic回归分析筛选IR的影响因素;构建模型并评估其诊断效能。结果 3组间体质量指数(BMI)、腰围、腰臀比(WHR),甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、谷丙转氨酶、谷草转氨酶、空腹血糖、C肽(C-PR)、空腹胰岛素(FINS),以及肝脏UDFF及Emean、胰腺UDFF及胰头、胰体、胰尾Emean差异均有统计学意义(P均<0.05)。IR组与对照组上述参数差异均有统计学意义(P均<0.05);IR组与非IR组腰围、WHR、TG、HDL、C-PR、FINS及肝脏UDFF差异有统计学意义(P均<0.05)。WHR、TG、FINS及肝脏UDFF均为肥胖/超重人群IR的独立影响因素(P均<0.05),四者联合的曲线下面积为0.935。结论 联合WHR、TG、FINS及肝脏UDFF诊断肥胖/超重人群IR效能较好,而胰腺UDFF对IR无显著影响。 |
| 英文摘要: |
| Objective To observe the value of ultrasound-derived fat fraction (UDFF) of liver and pancreas combined with clinical indicators for diagnosing insulin resistance (IR) in obese/overweight populations. Methods Totally 99 obese/overweight individuals were retrospectively included and divided into IR group (n=45) and non-IR group (n=54) based on the presence of IR,while 45 healthy physical examination participants were taken as controls (control group). Clinical and ultrasound parameters were compared among 3 groups and between each 2 groups. Logistic regression analysis was used to screen the impact factors of IR, then a model was constructed and its diagnostic efficacy was evaluated. Results Significant differences of body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, fasting blood glucose, C-peptide (C-PR), fasting insulin (FINS), liver UDFF and Emean, as well as of pancreatic UDFF and Emean of the head, body and tail of the pancreas were detected among 3 groups, also between IR group and control group (all P<0.05). Meanwhile, significant differences of waist circumference, WHR, TG, HDL, C-PR, FINS and liver UDFF were found between IR group and non-IR group (all P<0.05). WHR, TG, FINS and liver UDFF were all independent impact factors of IR in obese/overweight populations (all P<0.05), and the area under the curve of their combination was 0.935. Conclusion The combination of WHR, TG, FINS and liver UDFF had better efficacy for diagnosing IR in obese/overweight populations, while pancreatic UDFF had no significant impact on IR. |
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