| 贾璐,高伟,赵磊,吴慧,杨振兴,朱璐,窦亚娜,郝粉娥.CT动脉增强分数预测新辅助治疗联合外科手术用于结直肠癌效果[J].中国介入影像与治疗学,2026,23(6):329-333 |
| CT动脉增强分数预测新辅助治疗联合外科手术用于结直肠癌效果 |
| CT arterial enhancement fraction for predicting effect of neoadjuvant therapy combined with surgical resection for colorectal cancer |
| 投稿时间：2025-12-20 修订日期：2026-03-17 |
| DOI：10.13929/j.issn.1672-8475.2026.06.002 |
| 中文关键词: 结直肠肿瘤 体层摄影术，X线计算机 新辅助治疗 |
| 英文关键词:colorectal neoplasms tomography,X-ray computed neoadjuvant therapy |
| 基金项目:内蒙古自治区医师协会临床医学研究和临床新技术推广项目（YSXH2024KYF042）、内蒙古医科大学“创客培育”项目（101322025030）。 |
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| 中文摘要: |
| 目的 观察CT动脉增强分数（AEF）预测新辅助治疗（NAT）联合外科手术用于结直肠癌效果的价值。方法 回顾性纳入46例先后接受NAT及根治性手术切除的结直肠癌患者；根据术后病理结果将肿瘤退缩分级（TRG）0～2者归为有效组（n=27）、3级为无效组（n=19）。比较组间一般资料及CT资料，行相关性、logistic回归及受试者工作特征（ROC）曲线分析，观察各参数预测疗效效能。结果 组间NAT前后动脉期CT值差值（ΔA）、NAT前后AEF差值（ΔAEF）及其变化率（AEF%）差异均有统计学意义（P均＜0.05），且均与疗效呈正相关（P均＜0.05）。ΔA及ΔAEF是NAT联合外科手术治疗结直肠癌有效的独立预测因素，其曲线下面积（AUC）分别为0.739及0.795；二者联合的AUC为0.819，略高于各单一参数但差异均无统计学意义（P均＞0.05）。结论 ΔAEF有助于预测NAT联合外科手术用于结直肠癌效果；联合ΔA或可进一步提高其预测效能。 |
| 英文摘要: |
| Objective To observe the value of CT arterial enhancement fraction （AEF） for predicting the effect of neoadjuvant therapy （NAT） combined with surgical resection for colorectal cancer. Methods Totally 46 colorectal cancer patients who underwent NAT and radical surgical resection successively were retrospectively enrolled. According to postoperative pathological results，those with tumor regression grade （TRG） 0—2 were classified as effective group （n=27）， and of grade 3 were classified as ineffective group （n=19）. General information and CT data were compared between groups. The correlation， logistic regression and receiver operating characteristic （ROC） curve analyses were performed， and the efficacy of each parameter for predicting treatment outcomes was observed. Results The difference of arterial phase CT values before and after NAT （ΔA）， the difference （ΔAEF） and change rate of AEF （AEF%） before and after NAT were significantly different between groups （all P＜0.05）， which were all positively correlated with treatment outcomes （all P＜0.05）.ΔA and ΔAEF were both independent predictive factors of the effectiveness of NAT combined with surgical resection for colorectal cancer， with the area under the curve （AUC） of 0.739 and 0.795， respectively. The AUC of the combination of ΔA and ΔAEF was 0.819， slightly higher than that of eachparameter alone， but the differences were not significant （both P＞0.05）. Conclusion ΔAEF could help to predict the efficacy of NAT combined with surgical resection for colorectal cancer. Combining with ΔA might further improve its predictive efficacy. |
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