| 白敬淼,史苏娜,柴建爽,蔺晓娟.血小板/嗜酸性粒细胞比值联合超声心动图判断急性ST段抬高型心肌梗死患者血栓负荷并预测预后[J].中国介入影像与治疗学,2026,23(6):345-350 |
| 血小板/嗜酸性粒细胞比值联合超声心动图判断急性ST段抬高型心肌梗死患者血栓负荷并预测预后 |
| Platelet to eosinophil ratio combined with echocardiography for assessing thrombus burden and predicting prognosis in patients with acute ST-segment elevation myocardial infarction |
| 投稿时间：2026-03-19 修订日期：2026-05-27 |
| DOI：10.13929/j.issn.1672-8475.2026.06.005 |
| 中文关键词: 心肌梗死 血小板 嗜酸性粒细胞 超声心动描记术 经皮冠状动脉介入治疗 冠状动脉血栓形成 预后 高血栓负荷 |
| 英文关键词:myocardial infarction blood platelets eosinophils echocardiography percutaneous coronary intervention coronary thrombosis prognosis high thrombus burden |
| 基金项目:邢台市重点研发计划（2024ZC191）。 |
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| 中文摘要: |
| 目的 观察血小板/嗜酸性粒细胞比值（PER）联合超声心动图判断急性ST段抬高型心肌梗死（STEMI）患者血栓负荷并预测预后的价值。方法 前瞻性选取124例拟接受经皮冠状动脉介入（PCI）治疗的急性STEMI患者，根据冠状动脉造影结果分为高血栓负荷（HTB）组（n=56）与非HTB组（n=68）、根据PCI后主要不良心血管事件（MACE）分为MACE组（n=45）与非MACE组（n=79）。比较组间临床及超声资料，分析HTB及MACE的影响因素并评估判断及预测效能。结果 HTB组与非HTB组，以及MACE组与非MACE组之间，嗜酸性粒细胞（EOS）、PER、左心室射血分数（LVEF）、左心室收缩末期容积（LVESV）及左心室舒张末期容积（LVEDV）差异均有统计学意义（P均＜0.05）。PER及LVEF均为HTB及MACE的保护因素、而LVESV及LVEDV均为危险因素（P均＜0.05）。基于PER、LVEF、LVESV及LVEDV判断HTB的曲线下面积（AUC）分别为0.881、0.776、0.748及0.717，预测MACE的AUC分别为0.892、0.698、0.698及0.738；四者联合的AUC分别为0.939、0.934，均显著高于各单一参数（P均＜0.05）。结论 联合PER、LVEF、LVESV及LVEDV有助于判断急性STEMI患者血栓负荷及预测预后。 |
| 英文摘要: |
| Objective To observe the value of platelet to eosinophil ratio （PER） combined with echocardiography for assessing thrombus burden and predicting prognosis in patients with acute ST-segment elevation myocardial infarction （STEMI）. Methods Totally 124 patients with acute STEMI who would undergo percutaneous coronary intervention （PCI） were prospectively enrolled and divided into high thrombi burden （HTB） group （n=56） and non-HTB group （n=68） based on results of coronary angiography， also major adverse cardiovascular event （MACE） group （n=45） and non-MACE group （n=79） according to post-PCI MACE. Clinical and ultrasound data were compared between groups.The impact factors of HTB and MACE were screened， and their diagnostic and predictive efficacy were analyzed. Results Significant differences of eosinophils （EOS）， PER， left ventricular ejection fraction （LVEF）， left ventricular end systolic volume （LVESV） and left ventricular end diastolic volume （LVEDV） were found between HTB group and non-HTB group， also between MACE group and non-MACE group （all P＜0.05）. PER and LVEF were both protective factors， while LVESV and LVEDV were both risk factors of HTB and MACE（all P＜0.05）. The area under the curve （AUC） of PER， LVEF， LVESV and LVEDV for diagnosing HTB was 0.881， 0.776， 0.748 and 0.717， of predicting MACE was 0.892， 0.698， 0.698 and 0.738， respectively， while of the combination of them was 0.939 and 0.934， respectively， which was significantly higher than that of each parameter alone （all P＜0.05）. Conclusion The combination of PER， LVEF， LVESV and LVEDV was helpful for assessing thrombus burden and predicting prognosis in patients with acute STEMI. |
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