| 张鹏,高军喜.超声介导脂质体微泡治疗乳腺癌进展[J].中国介入影像与治疗学,2026,23(7):438-442 |
| 超声介导脂质体微泡治疗乳腺癌进展 |
| Progresses of ultrasound-mediated lipid-shelled microbubbles for treating breast cancer |
| 投稿时间：2026-04-10 修订日期：2026-06-27 |
| DOI：10.13929/j.issn.1672-8475.2026.07.011 |
| 中文关键词: 乳腺肿瘤 脂质体 微泡 超声检查 分子靶向治疗 |
| 英文关键词:breast neoplasms liposomes microbubbles ultrasonography molecular targeted therapy |
| 基金项目: |
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| 摘要点击次数: 37 |
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| 中文摘要: |
| 超声介导脂质体微泡（LMB）是靶向治疗乳腺癌领域的重大突破；依托超声空化效应与LMB的协同作用，可在大幅降低药物系统性毒性的同时显著提高疗效，但其临床转化尚面临生物安全性争议、微泡规模化生产瓶颈及缺乏大规模临床试验支持等挑战。本文就超声介导LMB治疗乳腺癌进展进行综述。 |
| 英文摘要: |
| Ultrasound-mediated lipid-shelled microbubbles （LMB） is an important breakthrough in the field of targeted therapy of breast cancer. Depending on synergistic effects of ultrasound cavitation and LMB，systemic drug toxicity could be significantly reduced， while therapeutic efficacy could be markedly improved. However， clinical translation of this technology still faces challenges such as biosafety controversies， bottlenecks in microbubble large-scale production， and lack of support from large-scale clinical trials. The progresses of ultrasound-mediated LMB for treating breast cancer were reviewed in this article. |
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