| 刘国平,葛美叶,李琳,任雅蔚,孔德茂,张妺,孟庆华,王子轩,王莉.经导管直接溶栓治疗下肢深静脉血栓形成的尿激酶量效分析[J].中国介入影像与治疗学,2013,10(1):11-14 |
| 经导管直接溶栓治疗下肢深静脉血栓形成的尿激酶量效分析 |
| Analysis on dose and effect of urokinase in patients with lower limb deep vein thrombosis treated with catheter-directed thrombolysis |
| 投稿时间：2012-10-22 修订日期：2012-12-22 |
| DOI： |
| 中文关键词: 导管插管溶栓术 静脉血栓形成 尿激酶 |
| 英文关键词:Catheter-directed Venous thrombosis Urokinase |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨经导管直接溶栓(CDT)治疗下肢深静脉血栓中尿激酶的合理用量。方法 将拟接受CDT的90例DVT患者随机分为3组:A组用小剂量尿激酶溶栓(每日用量<40万U),B组用中等剂量(每日用量40万~80万U),C组用大剂量(每日用量>80万U)进行溶栓治疗。比较3组的溶栓效果、溶栓时间及出血情况。结果 3组溶栓疗效差异有统计学意义(Hc=15.09,P<0.05),A组与B组疗效差异有统计学意义(t=1.99,P<0.05)。3组溶栓时间差异有统计学意义(F=4.92,P<0.05)。各组出血发生率差异无统计学意义(χ2=2.96,P>0.05),C组出血程度最重。结论 CDT治疗DVT安全有效,每日尿激酶用量在40万U~80万U时溶栓疗效好,且出血发生率低。 |
| 英文摘要: |
| Objective To analyze the reasonable dosage of urokinase in patients with lower limb deep vein thrombosis (DVT) treated with catheter-directed thrombolysis (CDT). Methods Ninety patients with DVT who would be treated with CDT were randomly divided into three groups.Patients in group A were given with low dose of urokinase (<400 000 U per day, in group B with medium dose (400 000 U-800 000 U per day), while group C with larger dose urokinase (>800 000 U per day). The thrombolysis effect, thrombolytic treatment time and hemorrhage situation were compared among the three groups. Results The thrombolytic therapy effect were different among three groups (Hc=15.09, P<0.05). The effect were different between group A and group B (t=1.99, P<0.05). Thrombolytic time difference had statistical significance (F=4.92, P<0.05). No statistical significance of hemorrhage was found among three groups (χ2=2.96, P>0.05). Hemorrhage of group C was the most serious. Conclusion CDT for treatment of DVT is safe and effective. Using urokinase 400 000-800 000 U per day, the thrombolytic effect is good, and the rate of hemorrhage remains low. |
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