| 李瑞阳,张建军,张巧丽,谢梅,李志强,陈懂燕,李思茵,汪涛.尼古丁成瘾男性镜像神经元系统脑区静息态功能连接变化[J].中国医学影像技术,2025,41(9):1498~1501 |
| 尼古丁成瘾男性镜像神经元系统脑区静息态功能连接变化 |
| Resting-state functional connectivity changes of mirror neuron system brain regions in male nicotine addicts |
| 投稿时间：2025-06-10 修订日期：2025-08-30 |
| DOI：10.13929/j.issn.1003-3289.2025.09.009 |
| 中文关键词: 男性|烟草使用障碍|镜像神经元|功能网络|磁共振成像 |
| 英文关键词:male|tobacco use disorder|mirror neurons|functional network|magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 观察尼古丁成瘾男性镜像神经元系统(MNS)脑区静息态功能连接(rs-FC)变化及其与成瘾程度的相关性。方法 前瞻性对25例尼古丁成瘾男性(成瘾组)及27名健康男性(对照组)行静息态功能MR扫描;比较组间一般资料及rs-FC值,并以相关性分析观察成瘾组rs-FC值与法氏烟草依赖评估量表(FTND)和吸烟严重度指数(HSI)量表评分的相关性。结果 组间受试者年龄和受教育年限差异均无统计学意义(P均＞0.05)。相比对照组,成瘾组左侧额下回(IFG.L)与右侧颞中回(MTG.R)及右侧枕中回(MOG.R)之间rs-FC值显著增加(GRF校正,体素水平P＜0.005,团块水平P＜0.05),而右侧梭状回(FFG.R)与右内侧和旁扣带脑回(DCG.R)、右侧辅助运动区(SMA.R)、左内侧额上回(SFGmed.L)及左侧辅助运动区(SMA.L)之间rs-FC值显著下降(GRF校正,体素水平P＜0.005,团块水平P＜0.05)。成瘾组IFG.L与MTG.R之间rs-FC值与HSI量表评分呈负相关(r=－0.457,P=0.022),与MOG.R之间rs-FC值与HSI量表及FTND评分均呈负相关(r=－0.440、－0.458,P=0.028、0.021)。结论 尼古丁成瘾男性MNS脑区rs-FC模式存在特异性改变,且与其成瘾程度相关。 |
| 英文摘要: |
| Objective To observe resting-state functional connectivity (rs-FC) changes of mirror neuron system (MNS) brain regions in male nicotine addicts, and to explore their correlations with the degree of addiction. Methods Twenty-five male nicotine addicts (addiction group) and 27 healthy males (control group) were prospectively recruited, and resting-state functional MR scanning was performed. The general information and rs-FC values were compared between groups, and correlations of rs-FC values with Fagerström test for nicotine dependence (FTND) and heaviness of smoking index (HSI) scale scores in addiction group were analyzed. Results No significant difference of age nor education level was found between groups (both P＞0.05). Compared to control group, rs-FC values between left inferior frontal gyrus (IFG.L) and right middle temporal gyrus (MTG.R) as well as right middle occipital gyrus (MOG.R) increased (GRF corrected, voxel-level P＜0.005, cluster-level P＜0.05), while between right fusiform gyrus (FFG.R) and right dorsal cingulate gyrus (DCG.R), right supplementary motor area (SMA.R), left medial superior frontal gyrus (SFGmed.L) and left supplementary motor area (SMA.L) decreased (GRF corrected, voxel-level P＜0.005, cluster-level P＜0.05). In addiction group, rs-FC value between IFG.L and MTG.R was negatively correlated with HSI scale score (r=－0.457, P=0.022), while that between IFG.L and MOG.R was negatively correlated with HSI scale and FTND scores (r=－0.440, －0.458, P=0.028, 0.021). Conclusion There were specific changes of rs-FC patterns of MNS brain regions in male nicotine addicts, which were correlated with the degree of addiction. |
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