| 刘飞,闫占月,甘郑宁,刘成环,王生兰,张林奎,刘刚.MR体素内不相干运动对比分析高原地区妊娠高血压综合征孕晚期与正常孕中-晚期孕妇胎盘微循环及微结构[J].中国医学影像技术,2025,41(9):1554~1557 |
| MR体素内不相干运动对比分析高原地区妊娠高血压综合征孕晚期与正常孕中-晚期孕妇胎盘微循环及微结构 |
| MR intravoxel incoherent motion for analysis of placental microcirculation and microstructures in plateau area of late pregnancy induced hypertension and normal middle and late pregnancy women |
| 投稿时间：2025-03-04 修订日期：2025-07-14 |
| DOI：10.13929/j.issn.1003-3289.2025.09.021 |
| 中文关键词: 高血压,妊娠引发|胎盘|微循环|磁共振成像|体素内不相干运动|高原 |
| 英文关键词:hypertension, pregnancy-induced|placenta|microcirculation|magnetic resonance imaging|intravoxel incoherent motion|plateau |
| 基金项目:青海省卫生健康委员会指导性课题(2019-wjzdx-75)。 |
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| 中文摘要: |
| 目的 观察MR体素内不相干运动(IVIM)用于分析高原地区妊娠高血压综合征(PIH)孕晚期与正常妊娠孕中-晚期孕妇胎盘微循环及微结构的价值。方法 回顾性纳入高原地区26例PIH孕晚期(A组)及46名正常妊娠孕妇[分为正常孕中期18名(B组) 及正常孕晚期28名(C组)],基于MR IVIM获取胎盘整体及胎盘胎儿侧、母体侧和中央区的灌注分数(f)、真实弥散系数(D)、伪弥散系数(D*)值并进行组内及组间比较;采用Pearson相关分析观察胎盘IVIM参数与孕妇年龄、孕周、估测胎儿体质量(EFW)及新生儿体质量的相关性。结果 C组胎盘母体侧f值大于胎儿侧(P＜0.05);各组内其余胎盘不同部位IVIM参数两两比较差异均无统计学意义(P均＞0.05)。A组整体胎盘及胎盘胎儿侧f值、整体胎盘及胎盘母体侧D值均小于C组(校正P均＜0.05);C组胎盘整体f及D*、胎盘母体侧f、D及D*、胎儿侧f及D*值均大于B组(校正P均＜0.05)。C组胎盘母体侧f值与孕周及EFW均呈负相关(r=－0.441、－0.579,P均＜0.01)。结论 利用 MR IVIM可无创分析高原地区PIH孕晚期与正常孕中-晚期孕妇胎盘微循环及微结构。 |
| 英文摘要: |
| Objective To observe the value of MR intravoxel incoherent motion (IVIM) for analyzing placental microcirculation and microstructures in plateau area of late pregnancy induced hypertension (PIH) and normal middle and late pregnancy. Methods Totally 26 cases of PIH in late-trimester of pregnancy (group A) and 46 normal pregnant women (including 18 normal middle-trimester[group B] and 28 normal late-trimester[group C]) in plateau area were retrospectively analyzed. The perfusion fraction (f), true diffusion coefficient (D) and pseudo-diffusion coefficient (D*) values of the entire placenta and the fetal side, maternal side and central region of placenta were obtained based on MR IVIM data, intra- and inter-group comparisons were conducted. Pearson correlation analysis was used to explore the relationships of placental IVIM parameters and maternal age, gestational age, estimated fetal weight (EFW) and neonatal birth weight. Results Except for f value of placental maternal side was higher than of fetal side in group C (P＜0.05), no significant difference was found in pairwise comparisons of IVIM parameters between different placental regions within each group (all P＞0.05). f value of the entire placenta and its fetal side, as well as D value of the entire placenta and its maternal side in group A were all higher than those in group C (all adjusted P＜0.05). The f and D* values of the entire placenta, f, D and D* values of its maternal side, as well as f and D* values of the fetal side in group C were all higher than those in group B (all adjusted P＜0.05). In group C, f value of placental maternal side was negatively correlated with both gestational age and EFW (r=－0.441, －0.579, both P＜0.01). Conclusion MR IVIM could be used to non-invasively assess placental microcirculation and microstructures in plateau area of late PIH and normal middle and late pregnancy women. |
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