| 刘敏,王茜,李利琼,李萍,胡谢,王丹.腔内超声参数联合临床特征预测多囊卵巢综合征伴不孕患者接受体外受精或卵母细胞细胞质内单精子注射后能否成功妊娠[J].中国医学影像技术,2025,41(9):1558~1562 |
| 腔内超声参数联合临床特征预测多囊卵巢综合征伴不孕患者接受体外受精或卵母细胞细胞质内单精子注射后能否成功妊娠 |
| Transvaginal ultrasound parameters combined with clinical features for predicting success pregnancy or not of polycystic ovary syndrome patients with infertility after in vitro fertilization/intracytoplasmic sperm injection |
| 投稿时间：2024-11-08 修订日期：2025-04-02 |
| DOI：10.13929/j.issn.1003-3289.2025.09.022 |
| 中文关键词: 多囊卵巢综合征|超声检查|治疗转归|预测 |
| 英文关键词:polycystic ovary syndrome|ultrasonography|treatment outcome|forecasting |
| 基金项目: |
|
| 摘要点击次数: 89 |
| 全文下载次数: 27 |
| 中文摘要: |
| 目的 观察腔内超声参数联合临床特征预测多囊卵巢综合征(PCOS)伴不孕患者接受体外受精或卵母细胞细胞质内单精子注射(IVF/ICSI)后能否成功妊娠的价值。方法 回顾性分析348例PCOS伴不孕患者,以IVF/ICSI后超声可见妊娠囊且4个月内未流产者为妊娠成功(妊娠组,n=178),否则为未妊娠(未妊娠组,n=170)。以单因素及多因素logistic回归分析临床资料、IVF/ICSI及腔内超声参数,筛选PCOS伴不孕患者IVF/ICSI后未能妊娠的独立预测因素并构建回归模型 ,评估其预测效能、校准度及临床价值。结果 患者年龄、不孕年限、促排卵方案(长方案)、注射促性腺激素时长,IVF/ICSI前超声显示窦卵泡数、优势卵泡数、卵巢总面积、卵巢髓质面积、子宫内膜厚度,以及是否IVF后形成2个原核(IVF 2PN)、是否ICSI后形成2个原核(ICSI 2PN)均为PCOS伴不孕患者IVF/ICSI后能否成功妊娠的独立预测因素(P均＜0.05)。以所获回归模型进行预测的曲线下面积为0.771,且其预测概率与实际概率相符。决策分析曲线示回归模型具有良好临床收益。结论 腔内超声参数联合临床特征可有效预测PCOS伴不孕患者接受IVF/ICSI后能否成功妊娠。 |
| 英文摘要: |
| Objective To explore the value of transvaginal ultrasound parameters combined with clinical features for predicting success pregnancy or not of polycystic ovary syndrome (PCOS) patients with infertility after in vitro fertilization /intracytoplasmic sperm injection (IVF/ICSI). Methods Totally 348 PCOS patients with infertility were retrospectively analyzed. Patients with presence of a gestational sac on ultrasound and did not experience miscarriage within 4 months after IVF/ICSI were classified as success pregnancy (pregnancy group, n=178), while the rest 170 patients were enrolled in non-pregnancy group. Univariable and multivariable logistic regression analyses were employed to assess clinical data, IVF/ICSI and transvaginal ultrasound parameters to identify the independent predictors of non-pregnancy in PCOS patients with infertility after IVF/ICSI, and a regression equation was constructed. The predictive efficacy, calibration and clinical value of this model were evaluated. Results Patients’ age, duration of infertility, ovulation induction protocol (long protocol), duration of gonadotropin treatment, numbers of antral follicles and dominant follicles, total ovarian area, ovarian medullary area and endometrial thickness showed on transvaginal ultrasound before IVF/ICSI, as well as IVF with 2 pronuclei (IVF 2PN) and ICSI with 2 pronuclei (ICSI 2PN) or not were all independent predictors of success pregnancy or not in PCOS patients with infertility after IVF/ICSI (all P＜0.05). The area under the curve of the regression model was 0.771, and its predicted probabilities correlated with actual probabilities. Decision curve analysis indicated that the regression model had good clinical benefit. Conclusion Transvaginal ultrasound parameters combined with clinical features could effectively predict success pregnancy or not in PCOS patients with infertility after IVF/ICSI. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
