| 尚庆庆,褚炳源,杨明,张函夕,李欣璐,冯泽,李伟庆,王丰.结构与功能MRI研究阿尔茨海默病连续体海马变化进展[J].中国医学影像技术,2025,41(9):1595~1599 |
| 结构与功能MRI研究阿尔茨海默病连续体海马变化进展 |
| Progresses of structural and functional MRI in research of hippocampal changes in Alzheimer disease continuum |
| 投稿时间：2025-03-21 修订日期：2025-07-16 |
| DOI：10.13929/j.issn.1003-3289.2025.09.030 |
| 中文关键词: 阿尔茨海默病|轻度认知障碍|海马|磁共振成像 |
| 英文关键词:Alzheimer disease|mild cognitive impairment|hippocampus|magnetic resonance imaging |
| 基金项目:黑龙江省自然科学基金(LH2023H065)、黑龙江中医药大学研究生创新科研项目(2024yjscx114)。 |
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| 中文摘要: |
| 阿尔茨海默病(AD)是以认知功能下降为特征的神经退行性疾病。AD连续体指AD从早期病理改变到出现明显临床症状的动态发展过程,为涵盖主观认知下降(SCD)阶段、轻度认知障碍(MCI)阶段及痴呆期的连续谱系。作为AD早期累及的关键脑区之一,海马(HP)与AD进展密切相关。MRI已广泛用于研究AD连续体中HP变化。本文就结构与功能MRI研究AD连续体HP变化进展进行综述。 |
| 英文摘要: |
| Alzheimer disease (AD) is a neurological disease characterized by cognitive decline. AD continuum refers to the dynamic development progression from early pathological changes to obvious clinical symptoms, covering the continuous spectrum of subjective cognition decline (SCD) stage, mild cognitive impairment (MCI) stage and dementia stage. As one of the key brain regions involved in early stage, hippocampus (HP) in AD continuum is closely related to the progression of disease. MRI has been widely used in the study of HP in the AD continuum. The progresses in structural and functional MRI research of HP changes in AD continuum were reviewed in this article. |
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